Document Detail

Chronic respiratory disease in premature infants caused by Chlamydia trachomatis.
MedLine Citation:
PMID:  3753987     Owner:  NLM     Status:  MEDLINE    
The relation between chronic respiratory disease and infection with Chlamydia trachomatis in premature infants was investigated to ascertain the aetiological importance of intrauterine C trachomatis infection and chronic respiratory disease in premature infants. Serum IgM antibodies against C trachomatis were determined by enzyme linked fluorescence assay. Sections of lung tissues obtained by biopsy and at necropsy were also tested for the presence of antigens using fluorescein conjugated monoclonal antibodies to C trachomatis. Of 16 sera from premature infants with chronic respiratory diseases clinically diagnosed as bronchopulmonary dysplasia or the Wilson-Mikity syndrome, five had IgM antibodies to C trachomatis L2 strain by enzyme linked fluorescence assay (titre greater than or equal to 1/500). Of 37 sera from premature infants with extremely low birth weights, two had IgM antibodies to C trachomatis. No specific IgM antibody was detected in 31 neonates who showed raised serum IgM concentrations but who did not have respiratory tract symptoms. C trachomatis was identified from two specimens of lung tissue obtained at necropsy from premature infants with chronic respiratory disease positive for IgM antibody. These findings indicate the aetiological importance of intrauterine C trachomatis infection in chronic respiratory disease in premature infants.
K Numazaki; S Chiba; K Kogawa; M Umetsu; H Motoya; T Nakao
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  39     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  AIM; IM    
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MeSH Terms
Chlamydia Infections / complications*
Chlamydia trachomatis / immunology
Chronic Disease
Fetal Diseases / complications
Immunoglobulin M / analysis
Infant, Newborn
Infant, Premature, Diseases / etiology*
Lung Diseases / etiology*,  immunology,  radiography
Reg. No./Substance:
0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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