Document Detail

Chronic renal insufficiency is an independent predictor of mortality in implantable cardioverter-defibrillator recipients.
MedLine Citation:
PMID:  17367356     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic renal insufficiency (CRI) has been associated with increased risk of cardiovascular morbidity and mortality. However, there is limited knowledge regarding this association and the effect of renal dysfunction on survival benefit in patients with implantable cardioverter-defibrillators (ICDs). METHODS: We investigated whether there was an association between CRI (defined as serum creatinine levels >or=1.5 mg/dL) and increased risk of mortality in ICD recipients. We retrospectively studied all patients (n = 336) followed within our ICD clinic in a 2.5-year period. CRI, ventricular tachycardia (VT), cardiomyopathy (CM), and mortality were recorded. Ischemic CM was defined as the presence of coronary artery disease (CAD) and left ventricular ejection fraction <or= 30%. RESULTS: Despite no significant difference in CAD and VT occurrence between CRI and non-CRI groups in the overall population, there was a significantly higher mortality rate in the CRI group (P < 0.0001). CONCLUSION: CRI is a significant independent predictor of mortality in ICD recipients. Further investigation is needed to determine whether prevention, early detection, and more aggressive intervention in the treatment of CRI will reduce the incidence of mortality in this population.
Carol Chen-Scarabelli; Tiziano M Scarabelli
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  30     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-05-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-6     Citation Subset:  IM    
VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA.
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MeSH Terms
Defibrillators, Implantable / statistics & numerical data*
Electric Countershock / instrumentation,  mortality*
Michigan / epidemiology
Proportional Hazards Models
Renal Insufficiency, Chronic / mortality*
Risk Assessment / methods*
Risk Factors
Survival Analysis
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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