| Chronic renal failure, parathyroid hormone and fatty acids oxidation in skeletal muscle. | |
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MedLine Citation:
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PMID: 3361755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatty acids are an important source of skeletal muscle energy, and certain data suggest oxidation of long-chain fatty acids (LCFA) may be impaired in uremia. This abnormality may in part be responsible for uremic myopathy. Uremia is associated with hyperparathyroidism and PTH affects muscle metabolism; PTH enhances muscle proteolysis and impairs muscle bioenergetics, and it is possible that PTH also affects fatty acids oxidation. The present study examined in rats the effects of 4 days administration PTH and of 21 days of chronic renal failure (CRF) with and without excess PTH on oxidation of LCFA and short-chain fatty acids (SCFA). Both 1-84 and 1-34 PTH impaired oxidation of LCFA but not of a SCFA (beta-hydroxybutyric acid) and reduced the activity of carnitine palmitoyl transferase (CPT). Inactivation of the PTH abolished its effects. CRF rats with intact parathyroid glands had also impaired oxidation of LCFA and of CPT activity. Parathyroidectomy in CRF rats normalized these abnormalities. Carnitine contents of muscle were not altered. The data show that PTH excess in normal or in CRF rats is associated with impaired oxidation of LCFA and this effect is due to reduction in the activity of CPT, a key enzyme for the transport of LCFA to mitochondrial matrix for beta-oxidation. The data demonstrate another toxic effect of PTH on muscle in CRF and provide an additional pathogenic mechanism for uremic myopathy. |
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Authors:
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M Smogorzewski; G Piskorska; P R Borum; S G Massry |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Kidney international Volume: 33 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-06-08 Completed Date: 1988-06-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 555-60 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Southern California, School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carnitine O-Palmitoyltransferase / metabolism Fatty Acids / metabolism* Kidney Failure, Chronic / enzymology, metabolism* Male Mitochondria, Muscle / metabolism Muscles / drug effects, metabolism* Oxidation-Reduction Parathyroid Hormone / pharmacology, physiology* Peptide Fragments / pharmacology Rats Rats, Inbred Strains Teriparatide Uremia / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AM 29955/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Parathyroid Hormone; 0/Peptide Fragments; 52232-67-4/Teriparatide; EC 2.3.1.21/Carnitine O-Palmitoyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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