Document Detail

Chronic recurrent angina.
MedLine Citation:
PMID:  482989     Owner:  NLM     Status:  MEDLINE    
The natural history of variant angina is described in a patient with multiple exacerbations and remissions over a period of several years. Constant in-hospital electrocardiographic monitoring for 26 days documented 569 episodes of ST elevation, 89% of which were asymptomatic. Episodes ranged in duration from 15 seconds to 11 1/2 minutes, with 4% of episodes associated with premature ventricular contractions. Over the course of hospitalization, the episodes of ST elevation decreased in frequency and length, as did episodes of pain. During this period, a number of therapeutic agents, including propranolol, indomethacin, and chlorpheniramine were evaluated using double-blind crossover trials. No agent had a significant beneficial effect on the course of the disease, and there was an increase in the length of episodes with high doses of propranolol. Because of the great variability in the course of this disease, only double-blind crossover trials should be allowed to dictate the efficacy of therapeutic agents.
R M Robertson; J B Breinig; D Robertson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  72     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1297-9, 1303     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris* / physiopathology
Angina Pectoris, Variant* / diagnosis,  drug therapy,  physiopathology
Chronic Disease
Follow-Up Studies
Middle Aged
Propranolol / therapeutic use
Remission, Spontaneous
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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