Document Detail


Chronic recordings of hypoglossal nerve activity in a dog model of upper airway obstruction.
MedLine Citation:
PMID:  10601168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of the hypoglossal nerve was recorded during pharyngeal loading in sleeping dogs with chronically implanted cuff electrodes. Three self-coiling spiral-cuff electrodes were implanted in two beagles for durations of 17, 7, and 6 mo. During quiet wakefulness and sleep, phasic hypoglossal activity was either very small or not observable above the baseline noise. Applying a perpendicular force on the submental region by using a mechanical device to narrow the pharyngeal airway passage increased the phasic hypoglossal activity, the phasic esophageal pressure, and the inspiratory time in the next breath during non-rapid-eye-movement sleep. The phasic hypoglossal activity sustained at the elevated level while the force was present and increased with increasing amounts of loading. The hypoglossal nerve was very active in rapid-eye-movement sleep, especially when the submental force was present. The data demonstrate the feasibility of chronic recordings of the hypoglossal nerve with cuff electrodes and show that hypoglossal activity has a fast and sustained response to the internal loading of the pharynx induced by applying a submental force during non-rapid-eye-movement sleep.
Authors:
M Sahin; D M Durand; M A Haxhiu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  87     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2197-206     Citation Subset:  IM; S    
Affiliation:
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.
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MeSH Terms
Descriptor/Qualifier:
Airway Obstruction / physiopathology*
Animals
Dogs
Electrodes, Implanted
Electrophysiology
Feasibility Studies
Hypoglossal Nerve / physiopathology*,  surgery
Sleep / physiology
Sleep, REM / physiology
Time Factors
Wakefulness / physiology
Work of Breathing
Grant Support
ID/Acronym/Agency:
HL50527/HL/NHLBI NIH HHS; HL61775/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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