Document Detail

Chronic progressive external ophthalmoplegia and myalgia associated with tubular aggregates.
MedLine Citation:
PMID:  8333245     Owner:  NLM     Status:  MEDLINE    
Tubular aggregates represent a distinct myopathological feature characterized by basophilic sharply demarcated irregularly shaped subsarcolemmal zones consisting of parallel double-walled tubules of unknown subcellular origin. They are found on rare occasions in a wide spectrum of myopathies, but their significance for the development of muscular symptoms has not yet been fully established. We describe a patient with chronic progressive external ophthalmoplegia (CPEO) associated with exercise-induced myalgia and tubular aggregates in skeletal muscle. The association of CPEO with tubular aggregates has not been reported before and represents an important differential diagnosis to other syndromes associated with CPEO, especially mitochondrial encephalomyopathies.
S Beyenburg; S Zierz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  87     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-16     Completed Date:  1993-08-16     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM    
Department of Neurology, University of Bonn, Germany.
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MeSH Terms
Diagnosis, Differential
Enzymes / metabolism
Exercise Test
Microscopy, Electron
Microtubules / ultrastructure*
Mitochondrial Encephalomyopathies / diagnosis,  pathology*
Muscles / pathology*
Neurologic Examination
Ophthalmoplegia, Chronic Progressive External / diagnosis,  pathology*
Reg. No./Substance:

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