| Chronic progressive deficits in neuron size, density and number in the trigeminal ganglia of mice latently infected with herpes simplex virus. | |
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MedLine Citation:
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PMID: 21371157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous epidemiological studies have proposed a link between herpes simplex virus (HSV) infection and several common chronic neuropsychiatric and neurodegenerative diseases. Experimental HSV infection of mice can lead to chronic behavioral and neurological deficits and chronic pain. While neuron injury and loss are well-documented consequences of the acute phase of infection, the pathologic consequences of latent HSV infection are poorly understood. To determine whether latent HSV infection can cause neuronal injury in mice, trigeminal ganglia (TG) derived from adult BALB/c mice 1, 12 and 31 weeks after corneal HSV type 1 (HSV-1) inoculation were analyzed for evidence of productive or latent HSV-1 infection, inflammation and changes in neuron size, density and number. We found that latent HSV-1 infection between 12 and 31 weeks after corneal virus inoculation was associated with inflammation and progressive deficits in mean neuron diameter, neuronal nucleus diameter, neuron density and neuron number in the TG relative to mock-infected controls. The extent of neuronal injury during latent infection correlated with the extent of inflammation. These studies demonstrate that latent HSV infection is associated with progressive neuronal pathology and may lead to a better understanding of the role of HSV infections in chronic neurological diseases. |
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Authors:
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Sandor Dosa; Karla Castellanos; Sarolta Bacsa; Eva Gagyi; S Krisztian Kovacs; Klara Valyi-Nagy; Deepak Shukla; Terence S Dermody; Tibor Valyi-Nagy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-04-03 |
Journal Detail:
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Title: Brain pathology (Zurich, Switzerland) Volume: 21 ISSN: 1750-3639 ISO Abbreviation: Brain Pathol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-22 Completed Date: 2011-12-23 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 9216781 Medline TA: Brain Pathol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 583-93 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Brain Pathology © 2011 International Society of Neuropathology. |
Affiliation:
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Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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metabolism Age Factors Analysis of Variance Animals Cell Count / methods Disease Models, Animal Disease Progression Female Gene Expression Regulation, Viral HIV Infections / pathology* Herpesvirus 1, Human / pathogenicity* Inflammation / etiology, virology Membrane Proteins / metabolism Mice Mice, Inbred BALB C Neurons / pathology*, virology Phosphoproteins / metabolism Time Factors Trigeminal Ganglion / pathology*, virology Viral Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R37 AI038296-13/AI/NIAID NIH HHS; R37 AI38296/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Lat protein, mouse; 0/Membrane Proteins; 0/Phosphoproteins; 0/Viral Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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