Document Detail

Chronic progressive deficits in neuron size, density and number in the trigeminal ganglia of mice latently infected with herpes simplex virus.
MedLine Citation:
PMID:  21371157     Owner:  NLM     Status:  MEDLINE    
Numerous epidemiological studies have proposed a link between herpes simplex virus (HSV) infection and several common chronic neuropsychiatric and neurodegenerative diseases. Experimental HSV infection of mice can lead to chronic behavioral and neurological deficits and chronic pain. While neuron injury and loss are well-documented consequences of the acute phase of infection, the pathologic consequences of latent HSV infection are poorly understood. To determine whether latent HSV infection can cause neuronal injury in mice, trigeminal ganglia (TG) derived from adult BALB/c mice 1, 12 and 31 weeks after corneal HSV type 1 (HSV-1) inoculation were analyzed for evidence of productive or latent HSV-1 infection, inflammation and changes in neuron size, density and number. We found that latent HSV-1 infection between 12 and 31 weeks after corneal virus inoculation was associated with inflammation and progressive deficits in mean neuron diameter, neuronal nucleus diameter, neuron density and neuron number in the TG relative to mock-infected controls. The extent of neuronal injury during latent infection correlated with the extent of inflammation. These studies demonstrate that latent HSV infection is associated with progressive neuronal pathology and may lead to a better understanding of the role of HSV infections in chronic neurological diseases.
Sandor Dosa; Karla Castellanos; Sarolta Bacsa; Eva Gagyi; S Krisztian Kovacs; Klara Valyi-Nagy; Deepak Shukla; Terence S Dermody; Tibor Valyi-Nagy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-03
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  21     ISSN:  1750-3639     ISO Abbreviation:  Brain Pathol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-22     Completed Date:  2011-12-23     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  583-93     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Brain Pathology © 2011 International Society of Neuropathology.
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MeSH Terms
Adaptor Proteins, Signal Transducing / metabolism
Age Factors
Analysis of Variance
Cell Count / methods
Disease Models, Animal
Disease Progression
Gene Expression Regulation, Viral
HIV Infections / pathology*
Herpesvirus 1, Human / pathogenicity*
Inflammation / etiology,  virology
Membrane Proteins / metabolism
Mice, Inbred BALB C
Neurons / pathology*,  virology
Phosphoproteins / metabolism
Time Factors
Trigeminal Ganglion / pathology*,  virology
Viral Proteins / metabolism
Grant Support
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Lat protein, mouse; 0/Membrane Proteins; 0/Phosphoproteins; 0/Viral Proteins

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