Document Detail

Chronic pressure-natriuresis relationship in dogs with inherited essential hypertension.
MedLine Citation:
PMID:  8305171     Owner:  NLM     Status:  MEDLINE    
A genetic model of essential hypertension in the dog was studied to describe the phenotypic expression of the arterial pressure, as well as to determine the relationship between mean arterial blood pressure (MAP), hormone, and renal excretory responses to four different levels of sodium intake (5, 40, 120, 240 mEq/day) delivered intravenously and isotonically. This model was developed at the University of Pennsylvania (U/Penn) and termed Pennsylvania hypertensive dogs (PHD). The MAP was recorded beat-by-beat, 24 h/day, in 16 dogs. Water and sodium balances were determined daily for 4 days at each level of intake and blood samples were collected on the last day of each salt step for analysis of plasma renin activity (PRA), atrial natriuretic peptide (ANP), aldosterone (ALDO), and vasopressin (AVP). After the study, the dogs were designated as hypertensive (PHD-HT) when the 24-h average MAP was greater than 110 mm Hg and systolic pressure was greater than 160 mm Hg. Dogs that failed to meet both criteria were designated as normotensive genetic controls (PHD-NT). Although sodium was retained during the first day of each increase of salt intake in both groups, a return to balance was observed within the 4 days. There was no apparent change in the slope of the chronic renal function curve in either group of PHD studied, although the PHD-HT exhibit a curve shifted to a higher level of MAP. Plasma hormone levels in both groups of PHD studied responded in a manner similar to normal mongrel dogs with reductions of PRA, ALDO, elevations of ANP, and no change in AVP.(ABSTRACT TRUNCATED AT 250 WORDS)
P E Papanek; K C Bovee; M M Skelton; A W Cowley
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  6     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-16     Completed Date:  1994-03-16     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  960-7     Citation Subset:  IM    
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
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MeSH Terms
Aldosterone / blood
Analysis of Variance
Arginine Vasopressin / blood
Atrial Natriuretic Factor / blood
Blood Pressure / physiology*
Circadian Rhythm / physiology
Hemodynamics / physiology
Hypertension / physiopathology*
Infusions, Intravenous
Natriuresis / physiology*
Renin / blood
Sodium / administration & dosage
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor; EC

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