| Chronic prenatal exposure to carbamazepine and perinatal outcomes of C3H/He mice. | |
| | |
MedLine Citation:
|
PMID: 14749669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: This study was undertaken to determine a daily therapeutic dose of carbamazepine and to measure its effect on reproductive performance and perinatal outcomes of mice. STUDY DESIGN: Adult C3H/He mice were given carbamazepine in rodent chow in either a 0.25% or a 1.0% mixture. Comparisons between doses included nongravid weight change, plasma drug steady-state concentrations, and response to a maximal electroshock seizure test. The strain was then fed either the preferred dose of carbamazepine or a placebo 1 week before starting to mate and throughout gestation to compare reproductive performance and offspring early development. RESULTS: Mice who ate the 0.25% carbamazepine mixture displayed no evoked seizure activity and, in contrast to the 1.0% mixture, did not lose weight. This daily dose of 542+/-35 mg/kg produced a trough steady-state plasma concentration that was consistent with a protective threshold in humans. Differences from placebo controls were not statistically significant for the number of cycles necessary to conceive or for the duration of gestation. The litter size, survival rates, birth weights, weight gain, and onset of eye openings and teeth eruptions of the pups were not statistically significant between the two groups. CONCLUSION: Long-term prenatal exposure to a subtoxic yet therapeutic dose of carbamazepine did not impair reproductive performance or early growth and development of exposed mice offspring. |
| | |
Authors:
|
H Dix Christensen; William F Rayburn; K Michael Parker; Christina L Gonzalez; Karen P Gold |
Related Documents
:
|
3349229 - Interactions of the imidazodiazepine ro 15-4513 with chemical convulsants. 7081159 - Paraldehyde toxicity during treatment of status epilepticus. 11282039 - Neonatal seizures. 12207869 - Reanalysis of carbamazepine and carbamazepine-epoxide pharmacokinetics after multiple d... 9642669 - Gyki 52466 [1-(4-aminophenyl)-4-methoxy-7,8-methylenedioxy-5h-2,3-benzodiazepine hydroc... 9181049 - Anticonvulsant and neurotoxicological properties of 4-amino-n-(2-ethylphenyl)benzamide,... 1758999 - The dose-response slope: a useful method for expressing the results of methacholine pro... 17627959 - Measurements of non-target organ doses using mosfet dosemeters for selected imrt and 3d... 9347919 - Effects of sodium sulfate on acute n-(3,5-dichlorophenyl)succinimide (ndps) nephrotoxic... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 190 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2004-01-29 Completed Date: 2004-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 259-63 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anticonvulsants / administration & dosage, blood, pharmacology* Body Weight / drug effects Carbamazepine / administration & dosage, blood, pharmacology* Dose-Response Relationship, Drug Female Mice Mice, Inbred C3H Pregnancy Pregnancy Outcome* Prenatal Exposure Delayed Effects* |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neutrophils are stimulated by syncytiotrophoblast microvillous membranes to generate superoxide radi...
Next Document: Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetu...