Document Detail


Chronic pancreatitis: report from a multicenter Italian survey (PanCroInfAISP) on 893 patients.
MedLine Citation:
PMID:  19097829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: No data on chronic pancreatitis in Italy are available yet. AIM: To evaluate demographic, clinical, diagnostic and therapeutic aspects in patients suffering from chronic pancreatitis. PATIENTS AND METHODS: Eligible patients were prospectively enrolled from 2000 to 2005. Information concerning demographic data, lifestyle risk factors, family and clinical history, associated factors (alcohol, autoimmunity, cystic dystrophy of the duodenal wall, obstruction, genetic mutations) concomitant diseases, diagnostic findings, and pharmacological, endoscopic and surgical therapy were gathered. RESULTS: 893 patients (74% males, mean age 53.7+/-15.2 years) were evaluated. 519/859 patients (60%) were drinkers and 555/840 (66%) were smokers. A strong positive correlation between drinking and cigarette consumption (R=0.53; p<0.0001) was found. Heavy alcohol consumption (>80g of alcohol/day for more than 5 years) was considered the most important risk factor in 300 patients (34%), obstruction in 238 (27%), alcohol and obstruction in 82 (9%), autoimmunity in 34 (4%), cystic dystrophy of the duodenal wall/groove pancreatitis in 55 (6%), gene mutations in 36 (4%), and none (idiopathic) in 148 (17%). Bile stones were diagnosed in 287 patients (33%) and cholecystectomy was performed in 329 patients (38%). Pancreatic calcifications were diagnosed in 547/879 patients (62%). Pancreatic surgery was performed in 273 patients (31%). Endoscopic sphincterotomy was performed in 371 patients (42%). Exocrine and endocrine insufficiency were found, respectively, in 373/834 (45%) and 275/885 patients (31%). CONCLUSIONS: An unexpected low frequency of alcohol abuse and new emerging associated risk factors for chronic pancreatitis were observed in Italy.
Authors:
L Frulloni; A Gabbrielli; R Pezzilli; A Zerbi; G M Cavestro; F Marotta; M Falconi; E Gaia; G Uomo; A Maringhini; M Mutignani; P Maisonneuve; V Di Carlo; G Cavallini;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2008-12-20
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  41     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-06-16     Revised Date:  2010-02-17    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  IM    
Affiliation:
Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy. luca.frulloni@univr.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alcohol Drinking / epidemiology
Comorbidity
Female
Health Surveys
Hospitalization / statistics & numerical data
Humans
Italy / epidemiology
Male
Middle Aged
Pancreatitis, Chronic / diagnosis,  epidemiology*,  therapy
Prospective Studies
Risk Factors
Smoking / epidemiology
Sphincterotomy, Endoscopic / statistics & numerical data
Investigator
Investigator/Affiliation:
Chiara Scattolini / ; Paolo Pederzoli / ; Guido Costamagna / ; Andrea Tringali / ; Lucio Gullo / ; Francesca Gavazzi / ; Francesco Di Mario / ; Giuliana Sereni / ; Paola Salacone / ; Sergio Pedrazzoli / ; Pier Giorgio Rabitti / ; Rosalia Patti / ; Calogero Surrenti / ; Andrea Galli / ; Gianruggiero Fronda / ; Donata Campra / ; G B Forte / ; Pietro Rocco / ; Fausto Chilovi / ; Alberto de'Guelmi / ; Franco Mosca / ; Marco Del Chiaro / ; Sergio Intini / ; Gianfranco Delle Fave / ; Vito Corleto / ; M Francesca Dore / ; Giuseppe Palasciano / ; Carlo Mansi / ; Fausto Barberani / ; Alessandro Gigliotti /
Comments/Corrections
Comment In:
Dig Liver Dis. 2010 Feb;42(2):156   [PMID:  19586805 ]

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