| Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet. | |
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MedLine Citation:
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PMID: 20660988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although chronic pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA), the relationship between chronic pancreatitis and PDA remains obscure. A critical obstacle to understanding the role of chronic pancreatitis is the lack of animal models. To develop one such model, mice were fed long-term with a choline deficient ethionine-supplemented (CDE) diet. Histological evaluation revealed that chronic pancreatitis, characterized by acinar atrophy, fibrosis and well-developed tubular complexes (TCs), was observed after 24 weeks of CDE diet treatment. Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor alpha (TGF alpha) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation. Neoplastic lesions were not found after 54 weeks of treatment, suggesting that a continuation of CDE diet or another insult is required for the development of PDA. |
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Authors:
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Satoshi Ida; Masaki Ohmuraya; Masahiko Hirota; Nobuyuki Ozaki; Sayaka Hiramatsu; Hitoshi Uehara; Hiroshi Takamori; Kimi Araki; Hideo Baba; Ken-ichi Yamamura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental animals / Japanese Association for Laboratory Animal Science Volume: 59 ISSN: 1881-7122 ISO Abbreviation: Exp. Anim. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604830 Medline TA: Exp Anim Country: Japan |
Other Details:
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Languages: eng Pagination: 421-9 Citation Subset: IM |
Affiliation:
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Insitute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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blood Animal Feed / adverse effects* Animals Biological Markers / metabolism Blotting, Western Choline Deficiency / complications*, pathology Disease Models, Animal Ethionine / administration & dosage, adverse effects* Female Glycoproteins / metabolism Mice Mice, Inbred C57BL Pancreas / drug effects, metabolism, pathology Pancreatitis, Chronic / etiology*, pathology Prostatic Secretory Proteins / metabolism Receptor, Epidermal Growth Factor / metabolism Transforming Growth Factor alpha / metabolism ras Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Glycoproteins; 0/Prostatic Secretory Proteins; 0/Spink3 protein, mouse; 0/Transforming Growth Factor alpha; 13073-35-3/Ethionine; EC 2.7.10.1/EGFR protein, mouse; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 3.2.1.-/Amylases; EC 3.6.5.2/ras Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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