Document Detail

Chronic pain and ultrarapid opioid detoxification.
MedLine Citation:
PMID:  17156115     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Availability of opiate substances through physicians and on the street has led to a rise in dependence and in addiction resulting in countless numbers of people hooked on these drugs. Long-term use of these agents results in reduction of endogenous supply of opiate replaced by these exogenous compounds. A technique known as Ultrarapid Detoxification (UROD) has been developed and appears more promising than conventional modalities. UROD has been modified over 3 decades resulting in a safe and an effective general anesthetic that results in hemodynamically stable withdrawal without manifestation of central nervous system hyperarousal. A cornerstone of this technique involves clonidine, which stimulates reuptake of catecholamines and allows for large doses of opioid antagonist to be delivered without significant changes in heart rate or blood pressure, displacing the opiate. Though techniques vary from center to center, safety should be paramount with the technique performed in an intensive care unit with trained professional anesthesiologists. Psychosocial issues should be evaluated by a trained addictionalist and most people will succeed from the UROD procedure without experiencing the horrible withdrawal syndrome. Patients must have realistic goals and be prepared to deal with psychosocial issues post-procedure.
Alan D Kaye; Ron E Banister; Jason M Hoover; Amir R Baluch; Scott Jacobs; Rinoo V Shah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pain practice : the official journal of World Institute of Pain     Volume:  5     ISSN:  1533-2500     ISO Abbreviation:  Pain Pract     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-07-18     Revised Date:  2007-08-03    
Medline Journal Info:
Nlm Unique ID:  101130835     Medline TA:  Pain Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-42     Citation Subset:  -    
Department of Anesthesiology, Rapid Detoxification Center, Louisiana State University School of Medicine, New Orleans, LA 70112, USA.
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Comment In:
Pain Pract. 2005 Jun;5(2):135   [PMID:  17177760 ]

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