Document Detail


Chronic ovine evaluation of a totally implantable electrical left ventricular assist system.
MedLine Citation:
PMID:  2597489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The totally implantable Novacor left ventricular assist system (LVAS) comprises a pump/drive unit (VAD), electronic control and power subsystem (ECP), variable volume compensator (VVC), and belt skin transformer (BST). The system is now undergoing chronic in vivo evaluation. Cumulative animal testing of VAD, VVC, and BST subsystems are 12.1, 4.9, and 43 years, respectively. The longest implants were 279 days for the VAD, 767 days for the VVC, and 1,148 days for the BST. A chronic implant of the total system was electively terminated at 260 days. The LVAS was powered via the BST. Continuously monitored hemodynamic and pump parameters have demonstrated normal hemodynamics and LVAS operation. Periodic VVC determinations suggest a 0.8 ml/day diffusive gas loss. Tether-free operation has been demonstrated with an Ag-Zn battery backpack. The animal was healthy and free of infection as indicated by routine hematologic, biochemical and serum enzyme determinations. Hemolysis is minimal (plasma free hemoglobin less than 5 mg%). Pump output ranged from 7 to 8 L/min. Severe valve calcification was the reason for elective termination at 260 days. This preclinical in vivo experience, and in vitro reliability studies, demonstrate efficacy of the total system.
Authors:
N Ramasamy; H Chen; P J Miller; J S Jassawalla; B A Greene; A Ocampo; L C Siegel; P E Oyer; P M Portner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO transactions / American Society for Artificial Internal Organs     Volume:  35     ISSN:  0889-7190     ISO Abbreviation:  ASAIO Trans     Publication Date:    1989 Jul-Sep
Date Detail:
Created Date:  1990-02-06     Completed Date:  1990-02-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8611947     Medline TA:  ASAIO Trans     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  402-4     Citation Subset:  IM    
Affiliation:
Novacor Division, Baxter Healthcare Corporation, Oakland, CA 94621.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Volume
Electric Power Supplies*
Equipment Design
Heart-Assist Devices*
Hemodynamics
Hemolysis
Sheep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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