| Chronic oral toxicity of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-l-phenylalanine 1-methyl ester, monohydrate (advantame) in the dog. | |
| | |
MedLine Citation:
|
PMID: 22036027 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Advantame (N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-l-phenylalanine 1-methyl ester, monohydrate), an N-substituted analog of aspartame, has been developed as a high-intensity sweetener. Groups of 4 dogs of each sex were treated at 0, 2000, 10,000, or 50,000ppm of advantame in the diet for 52weeks. Additional groups of 2 dogs/sex at the control, and mid- and high-dose groups were treated for 52weeks followed by a 6-week recovery period. There was no effect of treatment on mortality, body weight, organ weights, food consumption, or the results of ophthalmological, electrocardiographic, haematological, clinical chemistry or urinalysis examinations. No histopathological changes were associated with advantame treatment. The NOAEL was considered to be 50,000ppm, the highest concentration tested, which was equivalent to 2057 and 2139mg/kg body weight/day in males, and females, respectively. The results of the study support the safety of advantame for use as a high-intensity sweetener. |
| | |
Authors:
|
A Otabe; T Fujieda; T Masuyama |
Related Documents
:
|
2567437 - Effects on weight and metabolic rate of obese women of a 3.4 mj (800 kcal) diet. 22487727 - The impact of preconceptual diet on the outcome of reproductive treatments. 3984927 - Energy expenditure before and during energy restriction in obese patients. 3354487 - Familial resemblance in energy intake: contribution of genetic and environmental factors. 19411817 - Metabolic parameters after bioenterics intragastric balloon placement in obese patients. 7986787 - Changes in plasma phospholipid fatty acids and their relationship to disease activity i... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 49 Suppl 1 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
|
Languages: eng Pagination: S49-59 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Ajinomoto Co., Inc., 15-1 Kyobashi 1-Chome, Chuo-ku, Tokyo 104-8315, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic toxicity and carcinogenicity of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-?-aspartyl]-l-ph...
Next Document: Evaluation of the teratogenic potential of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-?-aspartyl]-l...