| Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 17023203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Chronic heart failure (CHF) is associated with abnormalities of skeletal muscle metabolism. This may be due to impaired oxygen delivery as a result of endothelial dysfunction. AIMS: We postulated that ascorbic acid would improve oxygen delivery to exercising muscle and improve skeletal muscle metabolism. METHODS: We studied skeletal muscle metabolism using (31)P magnetic resonance spectroscopy in 39 CHF patients. Endothelial function was assessed by changes in pulse wave velocity. Subjects were randomised to receive 4 g ascorbic acid daily for 4 weeks in a placebo-controlled double-blind study. RESULTS: Ascorbic acid significantly increased phosphocreatine utilization during exercise. In addition, glycolytic ATP synthesis increased in the ascorbic acid group (change in rate of ATP synthesis at 1 min -0.21+/-0.76 with placebo, 2.06+/-0.60 following ascorbic acid; p<0.05). Phosphocreatine and ADP recovery after exercise were not changed. The fall in pulse wave velocity during reactive hyperaemia was increased by ascorbic acid from -6.3+/-2.6% to -12.1+/-2.0% (p<0.05). CONCLUSIONS: These findings suggest that ascorbic acid increased both phosphocreatine utilization and glycolytic ATP synthesis during exercise in patients with CHF implying worsened skeletal muscle metabolism despite improvements in endothelial function. |
| | |
Authors:
|
Angus K Nightingale; Jenifer G Crilley; Nicholas C Pegge; Ernie A Boehm; Catherine Mumford; Doris J Taylor; Peter Styles; Kieran Clarke; Michael P Frenneaux |
Related Documents
:
|
15470653 - Prediction of mortality in chronic heart failure from peak oxygen consumption adjusted ... 18834463 - Atrial fibrillation is associated with decreased cardiac sympathetic response to isomet... 12373493 - Fulminant japanese spotted fever definitively diagnosed by the polymerase chain reactio... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-10-04 |
Journal Detail:
|
Title: European journal of heart failure Volume: 9 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-03-05 Completed Date: 2007-06-19 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 287-91 Citation Subset: IM |
Affiliation:
|
Bristol Heart Institute, Bristol University, Bristol, UK. drangus@doctors.org.uk <drangus@doctors.org.uk> |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
biosynthesis Aged Ascorbic Acid / blood, therapeutic use* Chronic Disease Double-Blind Method Endothelium, Vascular / drug effects*, physiopathology Female Great Britain Heart Failure / metabolism*, physiopathology Humans Magnetic Resonance Spectroscopy Male Middle Aged Muscle, Skeletal / drug effects*, metabolism Phosphocreatine / metabolism |
| Chemical | |
Reg. No./Substance:
|
50-81-7/Ascorbic Acid; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4.
Next Document: International variations in the treatment and co-morbidity of left ventricular systolic dysfunction:...