Document Detail

Chronic obstructive pulmonary disease and longitudinal changes in pulmonary function due to occupational exposure to respirable quartz.
MedLine Citation:
PMID:  23000825     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The present study sought to examine the long-term effects of exposure to respirable quartz on pulmonary function with particular focus on chronic obstructive pulmonary disease (COPD).
METHODS: The study is based on the Wismut cohort of former uranium miners. Spirometric data were ascertained together with quantitative estimates of cumulative exposure to respirable quartz for each of 1421 study subjects born between 1954 and 1956. The case definition for COPD is based on the criteria of the Global Initiative for Chronic Obstructive Lung Disease. Linear mixed regression models were fitted to identify significant determinants of longitudinal changes in lung function parameters.
RESULTS: An average of five spirometries were available for each miner. It was shown that cumulative exposure to 1 mg/m(3)-year respirable quartz leads, on average, to a relative reduction in forced expiratory volume in 1 s/ orced vital capacity (FEV(1)/FVC) of 2.75% (p<0.001). A nested case-control approach demonstrated that the risk for COPD stage I increases with increasing cumulative exposure to respirable quartz (OR 1.81 per 1 mg/m(3)-year).
CONCLUSIONS: This paper adds further evidence on the long-term effects of exposure to respirable quartz, which include a decline in pulmonary function parameters and an increase in the incidence of COPD.
Matthias Möhner; Norbert Kersten; Johannes Gellissen
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Publication Detail:
Type:  Journal Article     Date:  2012-09-21
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  70     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-02-13     Revised Date:  2013-12-19    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Forced Expiratory Volume
Inhalation Exposure / adverse effects
Longitudinal Studies
Lung / drug effects*,  physiopathology
Occupational Diseases / etiology*,  physiopathology
Occupational Exposure / adverse effects*
Pulmonary Disease, Chronic Obstructive / etiology*,  physiopathology
Quartz / adverse effects*
Risk Factors
Young Adult
Reg. No./Substance:
14808-60-7/Quartz; 4OC371KSTK/Uranium
Comment In:
Occup Environ Med. 2013 Dec;70(12):893-4   [PMID:  24174635 ]
Occup Environ Med. 2013 Dec;70(12):893   [PMID:  23759533 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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