Document Detail


Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.
MedLine Citation:
PMID:  12424628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IL-13 is strongly implicated in the development of asthma and chronic obstructive pulmonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P=0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P=0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P=0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P=0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD.
Authors:
T C T M van der Pouw Kraan; M Küçükaycan; A M Bakker; J M C Baggen; J S van der Zee; M A Dentener; E F M Wouters; C L Verweij
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes and immunity     Volume:  3     ISSN:  1466-4879     ISO Abbreviation:  Genes Immun.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-08     Completed Date:  2003-04-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100953417     Medline TA:  Genes Immun     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-9     Citation Subset:  IM    
Affiliation:
Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands. t.van_der_pouw_kraan.cell@med.vu.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Genetic Predisposition to Disease*
Humans
Immunoglobulin E / blood
Interleukin-13 / genetics*
Male
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic*
Pulmonary Disease, Chronic Obstructive / genetics*
Chemical
Reg. No./Substance:
0/Interleukin-13; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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