Document Detail


Chronic myeloid leukemia from basics to bedside.
MedLine Citation:
PMID:  10557038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery of the Philadelphia chromosome and its consistent involvement in chronic myeloid leukemia (CML) was the first time that a relationship between a cytogenetic abnormality and malignancy was demonstrated. This review will try to provide an insight into the molecular mechanisms underlying this disease and outline the therapeutical options for patients with CML.
Authors:
S Thijsen; G Schuurhuis; J van Oostveen; G Ossenkoppele
Related Documents :
3978848 - Semiautomated chromosome analysis. a clinical test.
12781448 - Amplification of the bcr/abl fusion gene clustered on a masked philadelphia chromosome ...
2788468 - Cml-t1: a cell line derived from t-lymphocyte acute phase of chronic myelogenous leukemia.
7938018 - Progressive de novo dna methylation at the bcr-abl locus in the course of chronic myelo...
11841178 - Selachian cytogenetics: a review.
3623558 - Genesis and systematization of cardiovascular anomalies and analysis of skeletal malfor...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia     Volume:  13     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1646-74     Citation Subset:  IM    
Affiliation:
Department of Hematology, Br 250, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bone Marrow Purging
Cell Transformation, Neoplastic / genetics
Cytogenetic Analysis
Fusion Proteins, bcr-abl / genetics,  immunology
Genes, abl / genetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*,  immunology,  pathology,  therapy*
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics,  immunology,  pathology,  therapy
Philadelphia Chromosome*
Signal Transduction / genetics
Chemical
Reg. No./Substance:
0/Fusion Proteins, bcr-abl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Forced expression of the leukemia-associated gene EVI1 in ES cells: a model for myeloid leukemia wit...
Next Document:  The role of homeobox genes in normal hematopoiesis and hematological malignancies.