Document Detail


Chronic myeloid leukemia from basics to bedside.
MedLine Citation:
PMID:  10557038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery of the Philadelphia chromosome and its consistent involvement in chronic myeloid leukemia (CML) was the first time that a relationship between a cytogenetic abnormality and malignancy was demonstrated. This review will try to provide an insight into the molecular mechanisms underlying this disease and outline the therapeutical options for patients with CML.
Authors:
S Thijsen; G Schuurhuis; J van Oostveen; G Ossenkoppele
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia     Volume:  13     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1646-74     Citation Subset:  IM    
Affiliation:
Department of Hematology, Br 250, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow Purging
Cell Transformation, Neoplastic / genetics
Cytogenetic Analysis
Fusion Proteins, bcr-abl / genetics,  immunology
Genes, abl / genetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*,  immunology,  pathology,  therapy*
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics,  immunology,  pathology,  therapy
Philadelphia Chromosome*
Signal Transduction / genetics
Chemical
Reg. No./Substance:
0/Fusion Proteins, bcr-abl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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