Document Detail

Chronic myeloid leukemia from basics to bedside.
MedLine Citation:
PMID:  10557038     Owner:  NLM     Status:  MEDLINE    
The discovery of the Philadelphia chromosome and its consistent involvement in chronic myeloid leukemia (CML) was the first time that a relationship between a cytogenetic abnormality and malignancy was demonstrated. This review will try to provide an insight into the molecular mechanisms underlying this disease and outline the therapeutical options for patients with CML.
S Thijsen; G Schuurhuis; J van Oostveen; G Ossenkoppele
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia     Volume:  13     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1646-74     Citation Subset:  IM    
Department of Hematology, Br 250, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
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MeSH Terms
Bone Marrow Purging
Cell Transformation, Neoplastic / genetics
Cytogenetic Analysis
Fusion Proteins, bcr-abl / genetics,  immunology
Genes, abl / genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*,  immunology,  pathology,  therapy*
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics,  immunology,  pathology,  therapy
Philadelphia Chromosome*
Signal Transduction / genetics
Reg. No./Substance:
0/Fusion Proteins, bcr-abl

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