Document Detail


Chronic myeloid leukaemia with marked thrombocytosis in a patient with thalassaemia major: complete haematological remission under the combination of hydroxyurea and anagrelide.
MedLine Citation:
PMID:  11841409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The co-existence of thalassaemia major and chronic myeloid leukaemia (CML) is a very rare event. We report a 32-year-old man with thalassaemia major whose progressively increasing leukocytosis and thrombocytosis led to the diagnosis of CML confirmed by the characteristic t(9;22)(q34;q11) chromosomal translocation and the bcr-abl (b3a2) DNA fusion. The patient was treated with hydroxyurea and anagrelide. This combination resulted in the satisfactory control of both the white blood cell and platelet counts, which has continued over the past 14 months with no major side-effects, albeit with no molecular response. The administration of hydroxyurea was also associated with a significant HbF increase.
Authors:
Ersi Voskaridou; Evangelos Terpos; Veroniki Komninaka; Eftyhios Eftyhiadis; Marina Mantzourani; Dimitris Loukopoulos
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  116     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-13     Completed Date:  2002-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  IM    
Affiliation:
Unit of Thalassaemia, Laikon General Hospital, Athens, Greece. dloukop@otenet.gr
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MeSH Terms
Descriptor/Qualifier:
Adult
Antisickling Agents / therapeutic use*
Drug Therapy, Combination
Humans
Hydroxyurea / therapeutic use*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood,  complications*,  drug therapy
Leukocyte Count
Male
Platelet Aggregation Inhibitors / therapeutic use*
Platelet Count
Quinazolines / therapeutic use*
Remission Induction
Thrombocytosis / blood,  complications,  drug therapy
beta-Thalassemia / blood,  complications*,  drug therapy
Chemical
Reg. No./Substance:
0/Antisickling Agents; 0/Platelet Aggregation Inhibitors; 0/Quinazolines; 0/anagrelide; 127-07-1/Hydroxyurea

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