Document Detail


t(7;11)(p15;p15) Chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion.
MedLine Citation:
PMID:  11841413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We encountered a patient with Philadelphia-negative chronic myeloid leukaemia, with t(7;11)(p15;p15), in whom acute leukaemia phase (acute myeloid leukaemia-M2 morphology) developed within a short period. We detected a novel gene fusion between NUP98 and HOXA11 both in the chronic phase and in the acute leukaemia phase in this case. Although it is well known that a fusion of NUP98-HOXA9 in myeloid malignancies is created by the t(7;11)(p15;p15), this case suggests the possibility that HOXA11 might be another partner gene for NUP98 in t(7;11)(p15;p15) leukaemia.
Authors:
Akitaka Suzuki; Yoshikazu Ito; Goro Sashida; Seiko Honda; Tomoko Katagiri; Takashi Fujino; Takuro Nakamura; Kazuma Ohyashiki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  116     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-13     Completed Date:  2002-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  170-2     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Tokyo Medical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Blotting, Southern
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 7
Female
Homeodomain Proteins / genetics
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics*
Middle Aged
Nuclear Pore Complex Proteins / genetics
Oncogene Proteins, Fusion / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Translocation, Genetic
Chemical
Reg. No./Substance:
0/Homeodomain Proteins; 0/NUP98-HOXA9 fusion protein, human; 0/Nuclear Pore Complex Proteins; 0/Oncogene Proteins, Fusion

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