Document Detail

Chronic myelogenous leukemia showing biphenotypic blast crisis followed by lineage switch to B lymphoblastic leukemia.
MedLine Citation:
PMID:  19446879     Owner:  NLM     Status:  MEDLINE    
Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid.
Seung Hwan Oh; Tae Sung Park; Hye Ran Kim; Ja Young Lee; Jae Hyun Kim; Jeong Hwan Shin; Jeong Nyeo Lee
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Publication Detail:
Type:  Case Reports; Letter     Date:  2009-05-17
Journal Detail:
Title:  Leukemia research     Volume:  33     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  e195-8     Citation Subset:  IM    
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MeSH Terms
Blast Crisis*
Bone Marrow / pathology
Cell Lineage*
In Situ Hybridization, Fluorescence
Leukemia, B-Cell / pathology*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*

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