Document Detail

Chronic myelogenous leukemia and benzene exposure: a systematic review and meta-analysis of the case-control literature.
MedLine Citation:
PMID:  19695237     Owner:  NLM     Status:  MEDLINE    
Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds ratios (ORs) for individual studies range from 0.73 to 1.2. The pooled OR is 1.003 with 95% confidence interval (CI) of 0.94-1.07 (p=0.98) for both a fixed effects model and a random effects model. The case-control literature indicates that chronic myelogenous leukemia does not appear to be related to benzene exposure.
Steven H Lamm; Arnold Engel; Kiran P Joshi; Daniel M Byrd; Rusan Chen
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2009-08-18
Journal Detail:
Title:  Chemico-biological interactions     Volume:  182     ISSN:  1872-7786     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2009-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
Consultants in Epidemiology and Occupational Health (CEOH), Washington, DC 20016, United States.
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MeSH Terms
Benzene / toxicity*
Case-Control Studies
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / etiology*
Occupational Exposure*
Reg. No./Substance:

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