Document Detail

Chronic, multiple tics of Gilles de la Tourette's disease. CSF acid monoamine metabolites after probenecid administration.
MedLine Citation:
PMID:  272137     Owner:  NLM     Status:  MEDLINE    
Central nervous system metabolism in six children and one adult with the syndrome of chronic multiple tics was studied by measuring the accumulation of acid metabolites of dopamine and serotonin (homovanillic acid [HVA] and 5-hydroxyindole-acetic acid [5-HIAA], respectively) in the CSF following probenecid administration. The accumulation of 5-HIAA was reduced in patients with multiple tics in contrast with other pediatric patients (N = 27). The degree of reduction in 5-HIAA relative to HVA appeared to be associated with the severity of the tic disorder. With dextroamphetamine, tic symptoms worsened, CSF HVA level decreased, and CSF 5-HIAA concentration increased. These findings suggest an association in Gilles de la Tourette's disease of reduced functioning of inhibitory serotonergic mechanisms and functional dopaminergic overactivity.
D J Cohen; B A Shaywitz; B Caparulo; J G Young; M B Bowers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  35     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-03-29     Completed Date:  1978-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-50     Citation Subset:  AIM; IM    
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MeSH Terms
Brain / metabolism*
Dextroamphetamine / diagnostic use
Dopamine / metabolism*
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Neural Pathways / physiopathology
Phenylacetates / cerebrospinal fluid*
Probenecid / diagnostic use*
Serotonin / metabolism*
Tourette Syndrome / cerebrospinal fluid*,  physiopathology
Reg. No./Substance:
0/Phenylacetates; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-64-9/Dextroamphetamine; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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