| Chronic, multiple tics of Gilles de la Tourette's disease. CSF acid monoamine metabolites after probenecid administration. | |
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MedLine Citation:
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PMID: 272137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central nervous system metabolism in six children and one adult with the syndrome of chronic multiple tics was studied by measuring the accumulation of acid metabolites of dopamine and serotonin (homovanillic acid [HVA] and 5-hydroxyindole-acetic acid [5-HIAA], respectively) in the CSF following probenecid administration. The accumulation of 5-HIAA was reduced in patients with multiple tics in contrast with other pediatric patients (N = 27). The degree of reduction in 5-HIAA relative to HVA appeared to be associated with the severity of the tic disorder. With dextroamphetamine, tic symptoms worsened, CSF HVA level decreased, and CSF 5-HIAA concentration increased. These findings suggest an association in Gilles de la Tourette's disease of reduced functioning of inhibitory serotonergic mechanisms and functional dopaminergic overactivity. |
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Authors:
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D J Cohen; B A Shaywitz; B Caparulo; J G Young; M B Bowers |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of general psychiatry Volume: 35 ISSN: 0003-990X ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-03-29 Completed Date: 1978-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 245-50 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain / metabolism* Child Dextroamphetamine / diagnostic use Dopamine / metabolism* Female Homovanillic Acid / cerebrospinal fluid* Humans Hydroxyindoleacetic Acid / cerebrospinal fluid* Male Neural Pathways / physiopathology Phenylacetates / cerebrospinal fluid* Probenecid / diagnostic use* Serotonin / metabolism* Tourette Syndrome / cerebrospinal fluid*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Phenylacetates; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-64-9/Dextroamphetamine; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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