Document Detail

Chronic mild reduction of cerebral perfusion pressure induces ischemic tolerance in focal cerebral ischemia.
MedLine Citation:
PMID:  16141423     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Neurons acquire tolerance to ischemic stress when preconditioning ischemia occurs a few days beforehand. We focused on collateral development after mild reduction of perfusion pressure to find an endogenous response of the vascular system that contributes to development of ischemic tolerance. METHODS: After attachment of a probe, the left common carotid artery (CCA) of C57BL/6 mice was occluded. The left middle cerebral artery (MCA) was subsequently occluded permanently on days 0, 1, 4, 14, and 28 (n=8 each). The change in cortical perfusion during MCA occlusion was recorded. A sham group of mice received only exposure of the CCA and MCA occlusion 14 days later. In apoE-knockout mice, the MCA was occluded 14 days after CCA occlusion or sham surgery. Infarct size and neurologic deficit were determined 4 days after MCA occlusion. RESULTS: Mice that had 45% to 65% of baseline perfusion after CCA occlusion were used. Cortical perfusion after MCA occlusion was significantly preserved in day 14 (47+/-16%) and day 28 (46+/-7%) groups compared with day 0 (28+/-8%), day 1 (33+/-19%), day 4 (29+/-16%), and sham groups (32+/-9%). Infarct size and neurologic deficits were also attenuated in day 14 and day 28 groups compared with other groups. In apoE-knockout mice, there was no significant difference in perfusion, neurologic deficits, or infarction size between groups with and without CCA occlusion. CONCLUSIONS: Chronic mild reduction of perfusion pressure resulted in preservation of cortical perfusion and attenuation of infarct size after MCA occlusion. These responses of collaterals were impaired in apoE-knockout mice.
Kazuo Kitagawa; Yoshiki Yagita; Tsutomu Sasaki; Shiro Sugiura; Emi Omura-Matsuoka; Takuma Mabuchi; Kohji Matsushita; Masatsugu Hori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-01
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  36     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2006-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2270-4     Citation Subset:  IM    
Division of Strokology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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MeSH Terms
Apolipoproteins E / genetics,  physiology*
Brain / pathology*
Brain Ischemia / therapy*
Capillaries / pathology
Carotid Arteries / pathology*
Carotid Artery, Common / pathology*
Cerebral Infarction / pathology
Infarction, Middle Cerebral Artery / pathology
Ischemia / pathology
Ischemic Preconditioning
Mice, Inbred C57BL
Mice, Knockout
Neurons / metabolism
Neuropsychological Tests
Time Factors
Reg. No./Substance:
0/Apolipoproteins E

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