| Chronic mexiletine therapy for suppression of ventricular arrhythmias. | |
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MedLine Citation:
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PMID: 2451577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred patients with a 70% or greater reduction of ventricular premature contractions (VPCs) from baseline during 12 weeks of mexiletine therapy were continued on treatment for an additional 9 months. Fifteen patients did not have follow-up examinations. The response of the remaining 85 patients during this extended period of open-label mexiletine administration is described. Holter recordings were scheduled at 3-month intervals during this period. At these examinations, between 69 and 80% of patients maintained the same 70% or greater level of VPC suppression observed at the start of the 9-month treatment period. Mean and median levels of VPCs/h at each examination were significantly reduced from premexiletine levels throughout the study (p less than 0.0001). Blood tests and electrocardiographic intervals did not vary. The most frequently used dosage of mexiletine during each 3-month treatment period was 600 mg/day (50.0-55.6% of patients). Side effects warranted discontinuation of therapy in 8% (8/97) of patients, while in 25% (22/85), clinical evaluation resulted in a change in dosage level. Within a setting similar to that of clinical practice, long-term mexiletine administration for non-life-threatening ventricular arrhythmias was effective and well tolerated. |
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Authors:
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M Duke |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 11 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-05-13 Completed Date: 1988-05-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 132-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Manchester Memorial Hospital, Connecticut. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Complexes, Premature
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drug therapy* Clinical Trials as Topic Dose-Response Relationship, Drug Electrocardiography* Female Heart Ventricles / drug effects Humans Long-Term Care Male Mexiletine / therapeutic use* Middle Aged Monitoring, Physiologic Tachycardia / drug therapy |
| Chemical | |
Reg. No./Substance:
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31828-71-4/Mexiletine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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