Document Detail


Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.
MedLine Citation:
PMID:  23280858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methamphetamine (METH) is a highly addictive and neurotoxic psychostimulant. Its use in humans is often associated with neurocognitive impairment. Whether this is due to long-term deficits in short-term memory and/or hippocampal plasticity remains unclear. Recently, we reported that METH increases baseline synaptic transmission and reduces LTP in an ex vivo preparation of the hippocampal CA1 region from young mice. In the current study, we tested the hypothesis that a repeated neurotoxic regimen of METH exposure in adolescent mice decreases hippocampal synaptic plasticity and produces a deficit in short-term memory. Contrary to our prediction, there was no change in the hippocampal plasticity or short-term memory when measured after 14 days of METH exposure. However, we found that at 7, 14, and 21 days of drug abstinence, METH-exposed mice exhibited a deficit in spatial memory, which was accompanied by a decrease in hippocampal plasticity. Our results support the interpretation that the deleterious cognitive consequences of neurotoxic levels of METH exposure may manifest and persist after drug abstinence. Therefore, therapeutic strategies should consider short-term as well as long-term consequences of methamphetamine exposure.
Authors:
Ashley North; Jarod Swant; Michael F Salvatore; Joyonna Gamble-George; Petra Prins; Brittany Butler; Mukul K Mittal; Rebecca Heltsley; John T Clark; Habibeh Khoshbouei
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-08
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  67     ISSN:  1098-2396     ISO Abbreviation:  Synapse     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-09-03     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-57     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Dopamine Agents / toxicity*
Hippocampus / physiology
Long-Term Potentiation / drug effects
Male
Memory, Short-Term / drug effects*
Methamphetamine / toxicity*
Mice
Mice, Inbred C57BL
Time Factors
Grant Support
ID/Acronym/Agency:
DA026947/DA/NIDA NIH HHS; NS071122/NS/NINDS NIH HHS; R01 DA026947/DA/NIDA NIH HHS; R01 NS071122/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Agents; 44RAL3456C/Methamphetamine
Comments/Corrections

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