Document Detail


Chronic maternal smoking and cord blood amino acid and enzyme levels at term.
MedLine Citation:
PMID:  11152908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the influence of chronic active maternal smoking on cord blood amino acid and enzyme levels at term. METHODS: The concentrations of 24 free amino acids, total protein, and five enzymes were measured in samples of maternal and fetal cord venous plasma from 24 nonsmokers who were not exposed to tobacco smoke and 24 chronic smokers. Cotinine levels were also measured in maternal plasma to evaluate fetal tobacco exposure. The pregnancies were between 37 and 40 weeks' gestation, were uncomplicated, and were delivered vaginally. RESULTS: Fetal weight was significantly (P <.01) lower in the smokers than in controls. A positive significant (P <.001) correlation was found between maternal and umbilical venous cotinine concentrations. Significantly lower concentrations of aspartic acid (P <.01), hydroxyproline (P <.05), threonine (P <.005), alanine (P <.05), alpha-aminobutyric acid (P <.001), methionine (P <.05), tyrosine (P <.001), phenylalanine (P <.01), and lysine (P <.05) were found in the venous cord plasma of the smokers compared with nonsmokers. The fetomaternal ratios were similar in both groups. The umbilical plasma alkaline phosphatase activity was significantly (P <.01) lower in the smokers than in the controls. CONCLUSION: Chronic maternal smoking is associated with alterations of protein metabolism and enzyme activity in fetal cord blood. These may be secondary to irreversible changes in the cellular functions of the trophoblast and may contribute to fetal growth restriction.
Authors:
E Jauniaux; V Biernaux; E Gerlo; B Gulbis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  97     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-02-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  AIM; IM    
Affiliation:
Academic Department of Obstetrics and Gynaecology, University College London, London, United Kingdom. e.jauniaux@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkaline Phosphatase / blood
Amino Acids / analysis*
Cotinine / blood
Female
Fetal Blood / chemistry*,  enzymology
Fetal Weight
Humans
Male
Pregnancy
Smoking / physiopathology*
Chemical
Reg. No./Substance:
0/Amino Acids; 486-56-6/Cotinine; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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