Document Detail


Chronic maternal dietary iodine deficiency but not thiocyanate feeding affects maternal reproduction and postnatal performance of the rat.
MedLine Citation:
PMID:  17821855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iodine deficiency disorders affect reproductive performance in the afflicted populations. Environmental iodine deficiency (ID) and goitrogens are important in their aetiology. We observed earlier that chronic maternal dietary ID but not goitrogen feeding altered the blood-brain barrier nutrient transport in adult rats. Whether similar differences exist in their effects on reproduction of dams and postnatal performance of the offspring has been assessed. Inbred, female, weaning WNIN rats were rendered hypothyroid by feeding for 8-12 weeks, a low iodine test diet or a control diet with added potassium thiocyanate (KSCN) (@ 25 mg/rat/day). Following mating with control males, they continued on their respective diets till their pups were weaned. Indices of reproductive performance such as percentage of conception, mortality of dams during pregnancy and parturition, litter size, and survival of pups till weaning were affected markedly by ID but not thiocyanate feeding. Neither ID nor thiocyanate feeding from conception or parturition affected their reproductive performance. Nevertheless, postnatal weight gain of pups was less in all the three ID groups but not thiocyanate fed dams. Rehabilitation of chronically ID pregnant dams from conception or parturition did not improve their pregnancy weight gain, litter size or birth weight of pups but decreased abortion and mortality of mothers during pregnancy and parturition. Rehabilitation improved the pups' postnatal weight gain but the effect was only moderate. Based on the results of the present study it may be suggested that maternal ID but not thiocyanate feeding affects reproductive performance and postnatal performance of their offspring.
Authors:
S Bala Tripura Sundari; L Venu; Y Sunita; M Raghunath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  45     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  603-9     Citation Subset:  IM    
Affiliation:
Division of Endocrinology and Metabolism, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500 007, India.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animals
Antithyroid Agents / chemistry*
Birth Weight
Female
Hypothyroidism
Iodine / chemistry,  deficiency*
Litter Size
Maternal Exposure
Mothers
Pregnancy
Pregnancy, Animal / drug effects
Rats
Thiocyanates / chemistry*,  pharmacology
Chemical
Reg. No./Substance:
0/Antithyroid Agents; 0/Thiocyanates; 333-20-0/potassium thiocyanate; 7553-56-2/Iodine

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