Document Detail


Chronic malnutrition caused by a corn-based diet lowers the threshold for pentylenetetrazol-induced seizures in rats.
MedLine Citation:
PMID:  8641237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of epilepsy is high in developing countries where malnutrition is prevalent. Although malnutrition is not a direct cause of seizures, chronic malnutrition may predispose the brain to seizures. In large undernourished human groups from Latin America, the most common sources of food are corn and corn derivatives. We used a rat model of chronic malnutrition, in which corn tortillas were the only solid food intake, to study the possible influence of malnutrition at late stages of brain development on the dynamics of experimental seizures induced by pentylenetetrazole (PTZ). The threshold and does of PTZ required to produce seizures were greatly reduced in malnourished rats. The model of malnutrition used in the study imitates a form of malnutrition common among large numbers of humans. Our results suggest that chronic malnutrition early in life induces changes that lower the seizure threshold and leave the brain more susceptible to seizures. Whether this observation relates to the high incidence of epilepsy in underdeveloped countries remains to be determined.
Authors:
G Palencia; M Calvillo; J Sotelo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsia     Volume:  37     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-12     Completed Date:  1996-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  583-6     Citation Subset:  IM    
Affiliation:
Department of Neuroimmunology, National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Brain / growth & development,  physiopathology
Diet / adverse effects*
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Nutrition Disorders / complications,  etiology*,  physiopathology
Pentylenetetrazole* / pharmacology
Rats
Rats, Wistar
Seizures / chemically induced*,  etiology
Zea mays / adverse effects*
Chemical
Reg. No./Substance:
54-95-5/Pentylenetetrazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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