Document Detail

Chronic macular edema medical treatment in Irvine-Gass syndrome: case report.
MedLine Citation:
PMID:  19882508     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The advent of intravitreal pharmacologic therapies opened a new perspective in the treatment of Irvine-Gass syndrome with potential side effects. In this case report we evaluated the efficacy of steroid sub-Tenon injection treatment in chronic macular edema. METHODS: Five sub-Tenon injections, each of 0.8 cc of 4 mg betamethasone, were performed at 1-week intervals, followed by a second cycle of 5 sub-Tenon injections with the same cadency injections 4 months after the first cycle in a 52-year-old Caucasian woman with post-cataract surgery macular edema (Irvine-Gass syndrome). RESULTS: At first examination, the patient showed a best spectacle-corrected visual acuity (BSCVA) of 0.52 (logMAR). Optical coherence tomography (OCT) showed a foveal thickness of 893+/-4 microm and total macular volume of 15.41 mm3. Eleven months after starting treatment, BSCVA was 0.39 (logMAR) with reduction in metamorphopsia and better color sensitivity. OCT showed a foveal thickness of 217 microm and total macular volume of 8.05 mm3. Differential map between the first and the last OCTs showed a foveal thickness reduction of 660 microm. CONCLUSIONS: The significant improvement observed in this case of postsurgical macular edema showed how sub-Tenon steroidal injections proved to be useful as a first-step therapy.
Alessandro Randazzo; Paolo Vinciguerra
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  20     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  IM    
Istituto Clinico Humanitas-Rozzano, Milano, Italy.
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MeSH Terms
Betamethasone / administration & dosage*
Chronic Disease
Diagnosis, Differential
Disease Progression
Follow-Up Studies
Glucocorticoids / administration & dosage*
Macular Edema / diagnosis,  drug therapy*,  etiology
Middle Aged
Phacoemulsification / adverse effects
Postoperative Complications
Tomography, Optical Coherence
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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