Document Detail

Chronic lymphocytic leukemic patients, resistant to chemotherapy.
MedLine Citation:
PMID:  3050384     Owner:  NLM     Status:  MEDLINE    
In four reported studies, intensive chemotherapy of various types was administered to large groups of patients with chronic lymphocytic leukemia (CLL) in advanced stages. About half of the patients were non-responders to the therapy. Resistance to therapy was also found in 12% of patients with early CLL and in 19 CLL patients who had in vitro radioresistant lymphocytes before therapy. The findings support the hypothesis of the heterogeneity of CLL patients and suggest the need for new methods for therapy of non-responders and for in vitro or in vivo tests to diagnose non-responders.
R Schrek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  26     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  227-8     Citation Subset:  IM    
Research Service, VA Hospital, Elmhurst, IL 60126.
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MeSH Terms
Antigens, Heterophile
Drug Resistance*
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*,  immunology
Reg. No./Substance:
0/Antigens, Heterophile

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