Document Detail

Chronic lymphocytic leukemic patients, resistant to chemotherapy.
MedLine Citation:
PMID:  3050384     Owner:  NLM     Status:  MEDLINE    
In four reported studies, intensive chemotherapy of various types was administered to large groups of patients with chronic lymphocytic leukemia (CLL) in advanced stages. About half of the patients were non-responders to the therapy. Resistance to therapy was also found in 12% of patients with early CLL and in 19 CLL patients who had in vitro radioresistant lymphocytes before therapy. The findings support the hypothesis of the heterogeneity of CLL patients and suggest the need for new methods for therapy of non-responders and for in vitro or in vivo tests to diagnose non-responders.
R Schrek
Related Documents :
19877054 - Clinical and histologic evidence of salivary gland restoration supports the efficacy of...
17923734 - Effects of gender on white blood cell populations and neutrophil-lymphocyte ratio follo...
144554 - The long term effects of radiation of t and b lymphocytes in the peripheral blood after...
9642494 - Flow cytometric analysis of lymphocyte subsets in migraine patients during and outside ...
22265324 - Relationship between baseline et-1 plasma levels and outcome in patients with idiopathi...
25107604 - Associations between glycated albumin or hemoglobin a1c and the presence of coronary ar...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  26     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  227-8     Citation Subset:  IM    
Research Service, VA Hospital, Elmhurst, IL 60126.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens, Heterophile
Drug Resistance*
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*,  immunology
Reg. No./Substance:
0/Antigens, Heterophile

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immunotherapy in acute myelogeneous leukemia (AML)--a tool for maintaining remission?
Next Document:  The potential significance of sulphated glycosaminoglycans as a common constituent of all amyloids: ...