Document Detail


Chronic lymphocytic leukemia: a tale of one or two signals?
MedLine Citation:
PMID:  23147791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The significant correlation between disease aggressiveness and the gene and protein structures of the B-cell receptors (BCRs) expressed on chronic lymphocytic leukemia (CLL) cells, together with the evidence for chronic activation of the BCR pathway, have led to the hypothesis that this leukemia initiates and progresses by selecting normal B lymphocytes reactive with a restricted set of (auto)antigens. A study recently published in Nature identified a novel signal-initiating interaction between the third complementary determining region of the IG heavy chain variable domain (HCDR3) and an epitope in the second framework region (FR2) that appears to be unique to CLL B cells and that calls into question the need for classical antigen binding in the activation and expansion of the leukemic cells. These findings are discussed in the context of available information about the antigen reactivity of CLL B cells and its potential role in clonal survival and drive.
Authors:
Nicholas Chiorazzi; Dimitar G Efremov
Publication Detail:
Type:  Journal Article     Date:  2012-11-13
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-08-13     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  182-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology,  metabolism
Calcium / metabolism
Complementarity Determining Regions / genetics,  metabolism
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*,  pathology
Mice
Mutation
Receptors, Antigen, B-Cell / chemistry,  genetics,  metabolism*
Signal Transduction
Chemical
Reg. No./Substance:
0/Complementarity Determining Regions; 0/Receptors, Antigen, B-Cell; SY7Q814VUP/Calcium
Comments/Corrections

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