| Chronic lymphocytic leukemia and hairy-cell leukemia. | |
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MedLine Citation:
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PMID: 1710506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The chronic lymphoid leukemias are a heterogeneous group of disorders with different immunologic, biologic, and clinical features. The most common of these are the B-cell diseases, chronic lymphocytic leukemia and its variants, including prolymphocytic leukemia and hairy cell leukemia. The increased use of immunophenotyping has identified a number of other less common but related disorders. Despite being clonal disorders, the chronic B-cell leukemias exhibit immunologic abnormalities in multiple other lineages, the mechanism for which is not clear. Fludarabine, 2'-deoxycoformycin, and 2-chlorodeoxyadenosine are purine analogues that have advanced the treatment of chronic B-cell leukemias. Fludarabine appears to be the single most effective agent for chronic lymphocytic leukemia, while 2'-deoxycoformycin and 2-chlorodeoxyadenosine are both extremely effective in hairy cell leukemia. A recently completed comparison of alpha-interferon with 2'-deoxycoformycin in hairy cell leukemia may redefine the standard therapy for this disorder. Continued interaction between laboratory and clinical scientists is essential for continued progress in these diseases. |
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Authors:
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B D Cheson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in oncology Volume: 3 ISSN: 1040-8746 ISO Abbreviation: Curr Opin Oncol Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-07-17 Completed Date: 1991-07-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007265 Medline TA: Curr Opin Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 54-62 Citation Subset: IM |
Affiliation:
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National Cancer Institute, Bethesda, Maryland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / therapeutic use B-Lymphocytes / pathology Chlorambucil / therapeutic use Humans Immunologic Factors / therapeutic use Interferon Type I / therapeutic use Leukemia, Hairy Cell* / immunology, pathology, therapy Leukemia, Lymphocytic, Chronic, B-Cell* / diagnosis, immunology, pathology, therapy Middle Aged Neoplasm Staging Palliative Care Pentostatin / therapeutic use Prognosis Splenectomy |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Immunologic Factors; 0/Interferon Type I; 305-03-3/Chlorambucil; 53910-25-1/Pentostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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