| Chronic lymphocytic leukemia-associated membranous glomerulopathy: remission with fludarabine. | |
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MedLine Citation:
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PMID: 10074608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In some individuals, chronic lymphocytic leukemia (CLL) may be associated with glomerular disease from membranous nephropathy with resultant nephrotic syndrome. CLL is characterized by abnormal immunoregulation with a malignant clonal proliferation of lymphocytes. The association between the abnormal clone and nephrotic syndrome is suggested in some cases by the remission of proteinuria with a reduction in abnormal lymphocyte number after treatment with antineoplastic agents. For the first time, we describe a patient with CLL and associated membranous glomerulopathy whose nephrotic syndrome remitted after treatment with fludarabine, a new purine analogue used in the treatment of refractory CLL. |
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Authors:
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H Butty; J Asfoura; F Cortese; M Doyle; G Rutecki |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 33 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E8 Citation Subset: IM |
Affiliation:
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Northeastern Ohio Universities College of Medicine (NEOUCOM), Affiliated Hospitals at Canton, OH, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use* Biopsy Female Glomerulonephritis, Membranous / diagnosis, drug therapy*, etiology Humans Kidney / pathology Leukemia, Lymphocytic, Chronic, B-Cell / complications* Vidarabine / analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 21679-14-1/fludarabine; 5536-17-4/Vidarabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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