Document Detail


Chronic lymph flow and transcapillary fluid flux during angiotensin II hypertension.
MedLine Citation:
PMID:  2260731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The roles of the transvascular fluid flux and lymph flow in the distribution of extracellular fluid volume during angiotensin II (ANG II) hypertension were evaluated in 11 conscious dogs. Similarly, the factors regulating the distribution of plasma protein across the microvasculature were assessed. By the second day of ANG II infusion, the thoracic duct lymph flow had increased 58% above control, transcapillary fluid flux had increased 45%, and plasma volume, sulfate space, and interstitial fluid volume remained close to control. In addition, the thoracic duct lymph protein transport had increased 34%, and the accompanying increase in transcapillary protein flux prevented any change in plasma protein mass. Also, at this time, the lymph flow and protein transport from subcutaneous tissue in the hind limb were not increased, and the permeability-surface area product of this region decreased 40%. The origin of the increased thoracic duct lymph flow on day 2 probably was from the splanchnic bed. In conclusion, the increased lymph flow during ANG II hypertension compensated for the increase in transcapillary fluid flux, thus preventing edema formation.
Authors:
J Valenzuela-Rendon; R D Manning
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  259     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1205-13     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II* / pharmacology
Animals
Biological Transport / drug effects
Blood Pressure / drug effects
Blood Volume / drug effects
Body Fluids / metabolism*
Capillaries / metabolism*
Dogs
Extracellular Space / metabolism
Hypertension / chemically induced,  metabolism,  physiopathology*
Lymph / metabolism,  physiology*
Proteins / metabolism
Sulfates / metabolism
Thoracic Duct / physiopathology
Time Factors
Grant Support
ID/Acronym/Agency:
HL-01222/HL/NHLBI NIH HHS; HL-11678/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Proteins; 0/Sulfates; 11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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