Document Detail


Chronic lung disease of prematurity and early childhood wheezing: Is foetal inflammatory response syndrome to blame?
MedLine Citation:
PMID:  25051540     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Long-lasting respiratory symptoms have a huge impact on the quality of life in prematurely born children.
AIMS: We aimed to investigate the perinatal and maternal risk factors involved in the development of chronic respiratory morbidity in preterm infants, with an emphasis on the importance of Foetal Inflammatory Response Syndrome (FIRS).
STUDY DESIGN: Prospective cohort study.
SUBJECTS: Demographic, antenatal, delivery and outcomes data were collected from 262 infants with less than 32 completed weeks of gestational age, over a 10-year period.
OUTCOME MEASURES: Presence of chronic lung disease of prematurity and early childhood wheezing.
RESULTS: In multivariate logistic regression analysis the presence of FIRS appears to be the most important risk factor for both, chronic lung disease of prematurity (OR 31.05, 95% CI 10.7-87.75, p<0.001) and early childhood wheezing (OR 5.63, 95% CI 2.42-13.05, p=0.01). In the alternative regression model for early childhood wheezing, with chronic lung disease included as a variable, the statistical significance of FIRS completely vanished (OR 1.15, 95% CI 0.39-3.34, p=0.79), whilst chronic lung disease became the most important risk factor (OR 23.45, 95% CI 8.5-63.25, p<0.001).
CONCLUSIONS: Prenatal and early neonatal events are of utmost importance in the development of chronic respiratory symptoms in children. The influence of FIRS on the development of chronic respiratory symptoms goes far beyond its impact on gestational age and may be related to direct inflammation-mediated lung tissue damage. CLD appears to be an intermittent step on the way from FIRS to ECW.
Authors:
Nada Sindičić Dessardo; Sandro Dessardo; Elvira Mustać; Srđan Banac; Oleg Petrović; Branimir Peter
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-19
Journal Detail:
Title:  Early human development     Volume:  90     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  493-499     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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