Document Detail

Chronic lung disease: oxygen dogma revisited.
MedLine Citation:
PMID:  11236035     Owner:  NLM     Status:  MEDLINE    
Since the discovery of retrolental fibroplasia, and the role of oxygen in its development, oxygen has been considered a double-edged sword in neonatal medicine, the utmost care being exercised in order not to give too much oxygen (1). However, the important observation that hypoxaemia might induce pulmonary vasoconstriction (2) and airway constriction (3) in infants at risk for bronchopulmonary dysplasia has resulted in only a minor upward adjustment of oxygen supplementation in many neonatal units. Since oxygen toxicity has long been linked not only to retinopathy of prematurity but also to bronchopulmonary dysplasia (4), it is relevant to ask whether an increased FiO2 might have any detrimental effects on babies.
O D Saugstad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  90     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-08     Completed Date:  2001-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  113-5     Citation Subset:  IM    
Department of Pediatric Research, The National Hospital, University of Oslo, Norway.
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MeSH Terms
Anoxia / complications
Bronchopulmonary Dysplasia / etiology
Chronic Disease
Infant, Newborn
Infant, Premature
Lung Diseases / diagnosis,  etiology,  prevention & control*
Oxidative Stress
Oxygen / adverse effects*
Retinopathy of Prematurity / etiology,  prevention & control
Reg. No./Substance:

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