Document Detail

Chronic lithium chloride infusions: conditioned suppression of food intake and preference.
MedLine Citation:
PMID:  6573880     Owner:  NLM     Status:  MEDLINE    
A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acquired when the available diet was novel but not when it was familiar. Effects of drug infusions on daily food intake were found to parallel those on aversion formation. Marked, persistent suppression of food intake was seen in drug-treated animals consuming a novel diet, but only transient declines were seen in those with a familiar diet. By separating the direct from the conditioned effects on food intake of chronic drug infusions, these studies provided strong evidence that learned food aversions can lead to anorexia.
I L Bernstein; L E Goehler
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  97     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-8     Citation Subset:  IM    
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MeSH Terms
Anorexia / psychology*
Avoidance Learning*
Body Weight
Conditioning, Classical
Eating Disorders / psychology*
Food Preferences*
Lithium / pharmacology*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:

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