| Chronic lithium chloride infusions: conditioned suppression of food intake and preference. | |
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MedLine Citation:
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PMID: 6573880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acquired when the available diet was novel but not when it was familiar. Effects of drug infusions on daily food intake were found to parallel those on aversion formation. Marked, persistent suppression of food intake was seen in drug-treated animals consuming a novel diet, but only transient declines were seen in those with a familiar diet. By separating the direct from the conditioned effects on food intake of chronic drug infusions, these studies provided strong evidence that learned food aversions can lead to anorexia. |
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Authors:
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I L Bernstein; L E Goehler |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Behavioral neuroscience Volume: 97 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 1983 Apr |
Date Detail:
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Created Date: 1983-07-15 Completed Date: 1983-07-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 290-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anorexia / psychology* Avoidance Learning* Body Weight Conditioning, Classical Eating Disorders / psychology* Female Food Preferences* Humans Lithium / pharmacology* Male Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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R01-CA26419/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-93-2/Lithium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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