Document Detail


Chronic leukocytosis associated with clozapine treatment.
MedLine Citation:
PMID:  20643637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clozapine is an important second-generation antipsychotic that is reserved for patients with refractory schizophrenia. Unfortunately, clozapine is also associated with a number of adverse effects, with agranulocytosis being one of the chief concerns. Interestingly, patients who receive clozapine treatment may occasionally experience elevations in their total white blood cell count (WBC). In some of these patients, the leukocytosis may be persistent. We report the case of a patient with refractory schizophrenia who is treated with clozapine and who experienced chronic leukocytosis. A brief review of the literature addressing clozapine-associated leukocytosis follows the case report.
Authors:
Michael A Sopko; Charles F Caley
Related Documents :
16581327 - Statin safety: an appraisal from the adverse event reporting system.
23038897 - The concepts of vínculo and dialectical spiral: a bridge between intra- and intersubje...
20836867 - Adverse effects of extra-articular corticosteroid injections: a systematic review.
23024727 - Transtibial ertl amputation for children and adolescents: a case series and literature ...
18159307 - Evaluation of the rubella surveillance system in quebec.
12637237 - Engineering controls for selected silica and dust exposures in the construction industr...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical schizophrenia & related psychoses     Volume:  4     ISSN:  1935-1232     ISO Abbreviation:  Clin Schizophr Relat Psychoses     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312513     Medline TA:  Clin Schizophr Relat Psychoses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
Affiliation:
Touro College of Pharmacy, New York, NY, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / adverse effects*,  therapeutic use
Chronic Disease
Clozapine / adverse effects*,  therapeutic use
Dose-Response Relationship, Drug
Drug Therapy, Combination
Humans
Leukocyte Count
Leukocytosis / chemically induced*
Male
Schizophrenia, Paranoid / drug therapy*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neurodevelopmental animal models of schizophrenia: role in novel drug discovery and development.
Next Document:  Cardiac disease classification using heart rate signals.