| Chronic leukocytosis associated with clozapine treatment. | |
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MedLine Citation:
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PMID: 20643637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clozapine is an important second-generation antipsychotic that is reserved for patients with refractory schizophrenia. Unfortunately, clozapine is also associated with a number of adverse effects, with agranulocytosis being one of the chief concerns. Interestingly, patients who receive clozapine treatment may occasionally experience elevations in their total white blood cell count (WBC). In some of these patients, the leukocytosis may be persistent. We report the case of a patient with refractory schizophrenia who is treated with clozapine and who experienced chronic leukocytosis. A brief review of the literature addressing clozapine-associated leukocytosis follows the case report. |
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Authors:
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Michael A Sopko; Charles F Caley |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical schizophrenia & related psychoses Volume: 4 ISSN: 1935-1232 ISO Abbreviation: Clin Schizophr Relat Psychoses Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312513 Medline TA: Clin Schizophr Relat Psychoses Country: United States |
Other Details:
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Languages: eng Pagination: 141-4 Citation Subset: IM |
Affiliation:
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Touro College of Pharmacy, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / adverse effects*, therapeutic use Chronic Disease Clozapine / adverse effects*, therapeutic use Dose-Response Relationship, Drug Drug Therapy, Combination Humans Leukocyte Count Leukocytosis / chemically induced* Male Schizophrenia, Paranoid / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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