Document Detail

Chronic leukocytosis associated with clozapine treatment.
MedLine Citation:
PMID:  20643637     Owner:  NLM     Status:  MEDLINE    
Clozapine is an important second-generation antipsychotic that is reserved for patients with refractory schizophrenia. Unfortunately, clozapine is also associated with a number of adverse effects, with agranulocytosis being one of the chief concerns. Interestingly, patients who receive clozapine treatment may occasionally experience elevations in their total white blood cell count (WBC). In some of these patients, the leukocytosis may be persistent. We report the case of a patient with refractory schizophrenia who is treated with clozapine and who experienced chronic leukocytosis. A brief review of the literature addressing clozapine-associated leukocytosis follows the case report.
Michael A Sopko; Charles F Caley
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical schizophrenia & related psychoses     Volume:  4     ISSN:  1935-1232     ISO Abbreviation:  Clin Schizophr Relat Psychoses     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312513     Medline TA:  Clin Schizophr Relat Psychoses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
Touro College of Pharmacy, New York, NY, USA.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Chronic Disease
Clozapine / adverse effects*,  therapeutic use
Dose-Response Relationship, Drug
Drug Therapy, Combination
Leukocyte Count
Leukocytosis / chemically induced*
Schizophrenia, Paranoid / drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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