Document Detail

Chronic kidney disease in pregnancy requiring first-time dialysis.
MedLine Citation:
PMID:  20542271     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report on the treatment and outcome of pregnancy in 29 women with chronic kidney disease (CKD), 24 of whom had moderate or severe renal dysfunction.
METHODS: Renal dysfunction at the onset of pregnancy was stratified: serum creatinine ≤1.4 mg/dL was defined as mild; 1.5-2.5 mg/dL was defined as moderate; and >2.5 mg/dL was defined as severe renal insufficiency. Clinical complications and perinatal outcomes were evaluated.
RESULTS: The average serum creatinine level at the beginning of pregnancy was 3.32 mg/dL (range, 1.2-7.1 mg/dL), and the average urine protein level was 1.51 g in 24 hours (range, 0.1-5.6g in 24 hours). Dialysis therapy was necessary for 1 woman with mild renal dysfunction, 4 patients with moderate renal dysfunction, and 17 patients with severe renal dysfunction.
CONCLUSION: The use of dialysis in pregnancy among women with moderate or severe renal dysfunction proved to be useful, but many patients became dependent on dialysis. It is not known whether this was due to the interaction between pregnancy and advanced CKD.
Jussara L Sato; Leandro De Oliveira; Gianna M Kirsztajn; Nelson Sass
Publication Detail:
Type:  Journal Article     Date:  2010-06-12
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  111     ISSN:  1879-3479     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  45-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Department of Obstetrics, Federal University of Sao Paulo, Sao Paulo, Brazil.
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MeSH Terms
Anemia / diagnosis,  epidemiology,  therapy
Creatinine / blood
Pregnancy Complications / therapy*
Proteinuria / therapy
Renal Dialysis*
Renal Insufficiency, Chronic / therapy*
Retrospective Studies
Severity of Illness Index
Treatment Outcome
Young Adult
Reg. No./Substance:

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