Document Detail

Chronic intrastriatal quinolinic acid produces reversible changes in perikaryal calbindin and parvalbumin immunoreactivity.
MedLine Citation:
PMID:  7523988     Owner:  NLM     Status:  MEDLINE    
We recently reported the use of a chronic dialytic delivery system for intrastriatal administration of quinolinic acid in the rat. This system produces neurodegeneration with some characteristics similar to post mortem brain tissue from Huntington's disease patients, including reduced cytochrome oxidase staining, a decreased number of Nissl-stained neurons, and relative sparing of striatal NADPH-diaphorase containing neurons. The present findings show that chronic dialytic delivery of quinolinic acid also produces a Huntington's disease-like pattern of reduced calbindin and parvalbumin perikaryal immunoreactivity that is reversed in rats allowed four to eight weeks' recovery after cessation of quinolinic acid. Furthermore, cytochrome oxidase staining and the number of Nissl-stained cells were unchanged in the region of transient calbindin and parvalbumin immunoreactive perikaryal staining alterations. These results suggest that changes in calbindin and parvalbumin perikaryal immunoreactivity provide a relatively sensitive measure of quinolinic acid induced neurotoxicity. The reversible nature of reduced perikaryal immunoreactivity suggests a premorbid state of neurotoxicity, possibly marked by cellular redistribution of calbindin and parvalbumin.
T J Bazzett; J B Becker; R C Falik; R L Albin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  60     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-24     Completed Date:  1994-10-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  837-41     Citation Subset:  IM    
Department of Neurology, University of Michigan, Ann Arbor 48104-1687.
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MeSH Terms
Calcium-Binding Protein, Vitamin D-Dependent / metabolism*
Corpus Striatum / cytology,  metabolism*
Dose-Response Relationship, Drug
Immunohistochemistry / methods
Neurons / cytology,  metabolism
Parvalbumins / metabolism*
Quinolinic Acid / administration & dosage,  pharmacology*
Staining and Labeling
Time Factors
Grant Support
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Parvalbumins; 0/calbindin; 89-00-9/Quinolinic Acid

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