| Chronic intrastriatal quinolinic acid produces reversible changes in perikaryal calbindin and parvalbumin immunoreactivity. | |
| | |
MedLine Citation:
|
PMID: 7523988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We recently reported the use of a chronic dialytic delivery system for intrastriatal administration of quinolinic acid in the rat. This system produces neurodegeneration with some characteristics similar to post mortem brain tissue from Huntington's disease patients, including reduced cytochrome oxidase staining, a decreased number of Nissl-stained neurons, and relative sparing of striatal NADPH-diaphorase containing neurons. The present findings show that chronic dialytic delivery of quinolinic acid also produces a Huntington's disease-like pattern of reduced calbindin and parvalbumin perikaryal immunoreactivity that is reversed in rats allowed four to eight weeks' recovery after cessation of quinolinic acid. Furthermore, cytochrome oxidase staining and the number of Nissl-stained cells were unchanged in the region of transient calbindin and parvalbumin immunoreactive perikaryal staining alterations. These results suggest that changes in calbindin and parvalbumin perikaryal immunoreactivity provide a relatively sensitive measure of quinolinic acid induced neurotoxicity. The reversible nature of reduced perikaryal immunoreactivity suggests a premorbid state of neurotoxicity, possibly marked by cellular redistribution of calbindin and parvalbumin. |
| | |
Authors:
|
T J Bazzett; J B Becker; R C Falik; R L Albin |
Related Documents
:
|
10999428 - Study of the effect of the administration of cd(ii), cysteine, methionine, and cd(ii) t... 17365708 - Preparation of ferulic acid derivatives and evaluation of their xanthine oxidase inhibi... 11349468 - Alkaptonuria: a case report. 16233628 - Characterization of two fructosyl-amino acid oxidase homologs of schizosaccharomyces po... 19492048 - Emergence of a code in the polymerization of amino acids along rna templates. 11453768 - Changes in nitrogen compounds in must and wine during fermentation and biological aging... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neuroscience Volume: 60 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 1994 Jun |
Date Detail:
|
Created Date: 1994-10-24 Completed Date: 1994-10-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 837-41 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University of Michigan, Ann Arbor 48104-1687. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calcium-Binding Protein, Vitamin D-Dependent / metabolism* Corpus Striatum / cytology, metabolism* Dialysis Dose-Response Relationship, Drug Immunohistochemistry / methods Neurons / cytology, metabolism Parvalbumins / metabolism* Quinolinic Acid / administration & dosage, pharmacology* Rats Staining and Labeling Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
NS00130/NS/NINDS NIH HHS; NS19613/NS/NINDS NIH HHS; NS22157/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Parvalbumins; 0/calbindin; 89-00-9/Quinolinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Release of immunoreactive galanin in the spinal cord of rats with ankle inflammation: studies with a...
Next Document: Temporal dissociation between changes in striatal enkephalin and substance P messenger RNAs followin...