Document Detail


Chronic intermittent stimulation of the thyroarytenoid muscle maintains dynamic control of glottal adduction.
MedLine Citation:
PMID:  10590405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with laryngeal motor control disorders need improved dynamic glottal closure for speech and swallowing. To evaluate the functional outcome of intermittent chronic thyroarytenoid muscle stimulation in an animal model, 6 canines were implanted with bilateral Medtronic Xtrel systems containing Peterson-type electrodes in the inferior and superior portions of the thyroarytenoid muscle. Stimulation was on one side only at 60 Hz, for 5 s on and 5 s off, over 8 h, 5 days per week, up to 8 months. Monthly videorecordings were done under anesthesia to measure the voltage threshold for detectable movement on each side, and vocal fold displacement and velocity during maximal stimulation of each side. Movement thresholds were lower in the inferior portion of the thyroarytenoid muscle (P </= 0.0005). Movement velocity was greater on the stimulated than on the nonstimulated side after 3 to 8 months (P = 0.039). No differences in the percentage distribution of different myosin heavy chain types were found between the stimulated and nonstimulated muscle samples. Sustained dynamic glottal adduction with no alteration in thyroarytenoid muscle function or fiber type was achieved with intermittent stimulation over 8 months. The results suggest that chronic intermittent thyroarytenoid stimulation has good potential for improving airway protection in dysphagia.
Authors:
C L Ludlow; S Bielamowicz; M Daniels Rosenberg; R Ambalavanar; K Rossini; M Gillespie; V Hampshire; R Testerman; D Erickson; U Carraro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  23     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-20     Completed Date:  2000-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-57     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
Affiliation:
Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5D38, 10 Center Drive, MSC 1416, Bethesda, Maryland, 20892-1416, USA. ludlowc@ninds.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Dogs
Electric Stimulation
Electrodes, Implanted
Electrophoresis, Polyacrylamide Gel
Female
Functional Laterality / physiology
Glottis / metabolism,  physiology*,  radiography
Laryngeal Muscles / metabolism,  physiology*,  radiography
Male
Myosin Heavy Chains / metabolism
Telemetry
Time Factors
Tomography, X-Ray Computed
Vocal Cords / physiology
Chemical
Reg. No./Substance:
0/Myosin Heavy Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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