Document Detail

Chronic intermittent in utero exposure to morphine: effects on respiratory control in the neonatal guinea pig.
MedLine Citation:
PMID:  9395840     Owner:  NLM     Status:  MEDLINE    
This study was done to determine if chronic intermittent in utero exposure to morphine (MOR) during the last half of gestation results in hypoventilation and decreased ventilatory sensitivity to CO2 in the neonate. Pregnant guinea pigs were randomly assigned to once-daily treatment with saline and 1.5, 5.0, or 15.0 mg/kg MOR. Neonates were studied for 3 weeks. Prenatal exposure to 5.0 and 15.0 mg/kg MOR significantly increased neonatal minute ventilation and central inspiratory drive on day 7 while breathing room air or 5% CO2. The increase in minute ventilation was part of a withdrawal syndrome that included increased locomotor activity, but was not due to an increase in metabolic rate or sensitivity to CO2. We conclude that neonatal guinea pigs exposed once daily to MOR during the last half of gestation hyperventilate during the 1st week after birth. These changes are neither permanent nor followed by hypoventilation or depressed sensitivity to CO2.
M A Hunter; G R Vangelisti; G D Olsen
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  72     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-03     Completed Date:  1998-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  293-304     Citation Subset:  IM    
Department of Physiology and Pharmacology, Oregon Health Sciences University School of Medicine, Portland, USA.
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MeSH Terms
Aging / drug effects
Analysis of Variance
Carbon Dioxide / metabolism
Dose-Response Relationship, Drug
Guinea Pigs
Hyperventilation / chemically induced*
Morphine / administration & dosage,  pharmacology*
Motor Activity / drug effects*
Oxygen Consumption / drug effects*
Prenatal Exposure Delayed Effects*
Random Allocation
Respiration / drug effects*
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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