| Chronic intermittent in utero exposure to morphine: effects on respiratory control in the neonatal guinea pig. | |
MedLine Citation:
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PMID: 9395840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was done to determine if chronic intermittent in utero exposure to morphine (MOR) during the last half of gestation results in hypoventilation and decreased ventilatory sensitivity to CO2 in the neonate. Pregnant guinea pigs were randomly assigned to once-daily treatment with saline and 1.5, 5.0, or 15.0 mg/kg MOR. Neonates were studied for 3 weeks. Prenatal exposure to 5.0 and 15.0 mg/kg MOR significantly increased neonatal minute ventilation and central inspiratory drive on day 7 while breathing room air or 5% CO2. The increase in minute ventilation was part of a withdrawal syndrome that included increased locomotor activity, but was not due to an increase in metabolic rate or sensitivity to CO2. We conclude that neonatal guinea pigs exposed once daily to MOR during the last half of gestation hyperventilate during the 1st week after birth. These changes are neither permanent nor followed by hypoventilation or depressed sensitivity to CO2. |
Authors:
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M A Hunter; G R Vangelisti; G D Olsen |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of the neonate Volume: 72 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1997 |
Date Detail:
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Created Date: 1998-02-03 Completed Date: 1998-02-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 293-304 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Oregon Health Sciences University School of Medicine, Portland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects Analysis of Variance Animals Carbon Dioxide / metabolism Dose-Response Relationship, Drug Female Guinea Pigs Hyperventilation / chemically induced* Male Morphine / administration & dosage, pharmacology* Motor Activity / drug effects* Oxygen Consumption / drug effects* Pregnancy Prenatal Exposure Delayed Effects* Random Allocation Respiration / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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DA 07912/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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