Document Detail

Chronic inhibition of nitric oxide synthase in Heymann nephritis.
MedLine Citation:
PMID:  8883033     Owner:  NLM     Status:  MEDLINE    
Effects of nitric oxide (NO) synthase inhibition on blood pressure and on the course of Heymann nephritis was examined in rats. L-NG-nitroarginine-methylester (L-NAME, 10 mg/100 ml in the drinking water for 12 weeks) was used as an inhibitor of NO synthase. Urinary excretion of guanosine 3',5'-cyclic monophosphate (cGMP), a second messenger of NO, was used as an indirect estimate of NO activity. Rats were divided into the following groups: control, nephritis, L-NAME, and nephritis-L-NAME. Urinary cGMP excretion was lower in the nephritis group (p < 0.05) and in the nephritis-L-NAME group (p < 0.005) compared with controls. Plasma atrial natriuretic peptide (ANP) levels were elevated in the nephritis (p < 0.001) and in the nephritis-L-NAME groups (p < 0.05. L-NAME treatment alone did not have any effect on plasma ANP levels. Blood pressure rose progressively in all L-NAME-treated rats. Most marked albuminuria developed in the nephritis-L-NAME group. No differences in the immunohistological findings were observed between the nephritis and the nephritis-L-NAME groups. NO synthase inhibition causes hypertension and aggravates albuminuria in chronic nephritis. Moreover, nephritis itself may decrease then production of cGMP either as a consequence of blunted NO activity or, in addition, because of ANP resistance. It appears that NO synthase inhibition does not change the immunological course of Heymann nephritis but rather the increased hemodynamic load makes the course of nephritis worse.
N Uhlenius; I Tikkanen; T Tikkanen; A Miettinen; T Törnroth; F Fyhrquist
Related Documents :
1451153 - Haemodynamic and neurohumoral response in heart failure produced by rapid ventricular p...
8036913 - Thoracic impedance and pulmonary atrial natriuretic peptide during head-up tilt induced...
3048093 - The evolution of current hypertension therapy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  74     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Minerva Foundation Institute for Medical Research, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Atrial Natriuretic Factor / blood
Autoimmune Diseases / chemically induced
Blood Pressure
Complement C3 / analysis
Cyclic GMP / urine
Enzyme Inhibitors / pharmacology
Glomerulonephritis / drug therapy,  metabolism*,  physiopathology
Immunoglobulin G / analysis
Kidney Glomerulus / chemistry,  pathology
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / physiology
Nitric Oxide Synthase / antagonists & inhibitors*
Rats, Wistar
Renin / blood
Time Factors
Reg. No./Substance:
0/Complement C3; 0/Enzyme Inhibitors; 0/Immunoglobulin G; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC Oxide Synthase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Renal effects of acute and chronic nitric oxide inhibition in experimental diabetes.
Next Document:  Calcium entry stimulated by swelling of Madin-Darby canine kidney cells.