Document Detail

Chronic ingestion of dietary fat is a prerequisite for inhibition of feeding by enterostatin.
MedLine Citation:
PMID:  9688701     Owner:  NLM     Status:  MEDLINE    
Enterostatin (Ent), the activation pentapeptide from procolipase, inhibits the intake of dietary fat. The selectivity of the response to fat suggests that the rat must recognize a permissive signal related to dietary fat for the Ent biological response. To investigate the nature of this signal, we studied the effects of Ent in rats that were adapted to either a high-fat (HF) or high-carbohydrate/low-fat (HC) diet and then naively exposed to either HF or HC diets. Ent (1 nmol) was injected into the lateral ventricle of overnight-fasted rats, and food intake was measured. Rats adapted to HF diet and tested with HC diet responded to Ent, but rats adapted to HC diet and tested with HF did not respond to Ent. The groups were maintained on their new test diets for up to 21 days and tested again for their response to Ent at 3, 7, 14, and 21 days. Ent response did not appear in HC-adapted rats switched to HF diet before 21 days. Conversely, the HF-adapted rats, which responded to Ent when tested with HC diet for the first time, did not respond at any subsequent testing time. The data suggest that chronic ingestion of dietary fat is required for Ent action and that chronic consumption of fat initiates a postingestion metabolic, endocrine, or neurochemical change that is required for the biological response to Ent.
L Lin; D A York
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-16     Completed Date:  1998-09-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R619-23     Citation Subset:  IM    
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
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MeSH Terms
Cerebral Ventricles / drug effects,  physiology*
Colipases / administration & dosage,  pharmacology*
Diet, Fat-Restricted*
Dietary Carbohydrates
Dietary Fats*
Energy Intake / drug effects*,  physiology
Enzyme Precursors
Injections, Intraventricular
Protein Precursors / administration & dosage,  pharmacology*
Rats, Sprague-Dawley
Grant Support
45278//PHS HHS
Reg. No./Substance:
0/Colipases; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Enzyme Precursors; 0/Protein Precursors; 72994-53-7/procolipase

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