Document Detail


Chronic inflammatory demyelinating polyradiculoneuropathy in children: characterized by subacute, predominantly motor dominant polyeuropathy with a favorable response to the treatment.
MedLine Citation:
PMID:  20003085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Chronic inflammatory demyelinating polyradiculopathy (CIDP) is less well-studied in children than in adults, probably due to its relative rarity. This study was performed in order to characterize the clinical features of CIDP in children. MATERIALS AND METHODS: Twenty-eight patients with CIDP who were followed up for more than 1 year were included, and were divided into a child (n = 7, age <16) and an adult group (n = 21, age >or=16). Then, we have assessed the initial progression pattern, clinical course, and serial nerve conduction findings in each patient. Finally, differential features in child and adult group were analyzed. RESULTS: Distinguishing features in the child group include subacute progression within less than 2 months, predominant motor system involvement in lower extremities, and marked improvement in response to immune modulating therapy. Our study also suggested that serial nerve conduction study may be useful in assessing the effectiveness of the treatment in children. CONCLUSIONS: Our study showed that children with CIDP have some distinguishing features from adults in terms of clinical course and response to treatment.
Authors:
H Y Jo; M-G Park; Dae-Seong Kim; S-O Nam; K-H Park
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Publication Detail:
Type:  Journal Article     Date:  2009-12-10
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  121     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  342-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
Humans
Immunologic Factors / therapeutic use*
Male
Middle Aged
Neural Conduction
Peripheral Nerves / physiopathology*
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / drug therapy*,  physiopathology*
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Immunologic Factors

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