Document Detail


Chronic inflammatory demyelinating polyneuropathy.
MedLine Citation:
PMID:  16631367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic inflammatory demyelinative polyneuropathy (CIDP) is an acquired neuropathy, presumably of immunological origin. Its clinical presentation and course are extremely variable. CIDP is one of the few peripheral neuropathies amenable to treatment. Typical cases associate progressive or relapsing-remitting motor and sensory deficit with increased CSF protein content and electrophysiological features of demyelination. In other instances the neuropathy is predominantly or exclusively motor or sensory, CSF normal and electrophysiological studies fail to show evidence of demyelination. In such cases conventional diagnostic criteria are not filled yet the patient may respond to immunomodulatory treatments. In this paper we review the diagnostic pitfalls and clinical variants of CIDP to illustrate the problems that may arise. The different therapeutic options are reviewed. Axon loss associated with demyelination is the most important factor of disability and resistance to treatment.
Authors:
Gérard Said
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  16     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-303     Citation Subset:  IM    
Affiliation:
Service de Neurologie, Hôpital de Bicêtre, Assistance Publique Hopitaux de Paris, Université Paris-Sud, 94275 Le Kremlin-Bicêtre, France. gerard.said@bct.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Autoantibodies / immunology
Axons / immunology,  pathology*
Child
Diagnosis, Differential
Disease Progression
Female
Humans
Immunosuppressive Agents / therapeutic use
Male
Middle Aged
Myelin Sheath / immunology,  pathology
Peripheral Nerves / immunology,  pathology*,  physiopathology*
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*,  drug therapy,  physiopathology*
Recurrence / prevention & control
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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