| Chronic inflammation in FMF: markers, risk factors, outcomes and therapy. | |
| | |
MedLine Citation:
|
PMID: 21060333 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Familial Mediterranean fever (FMF) is the most common of the hereditary periodic fever syndromes. Although the typical clinical course of FMF is characterized by bouts of painful inflammation, this presentation represents only the tip of the iceberg. In many patients inflammation can persist in attack-free periods, as shown by high levels of acute-phase proteins, cytokines and inflammation-induced proteins. This subclinical inflammation puts patients at risk of developing complications such as anemia, splenomegaly, decreased bone mineral density, heart disease and life-threatening amyloid A amyloidosis, among others. In this article, we review the published data on markers and other factors involved in the persistence of inflammation in patients with FMF during attack-free periods, examine the risk factors for the development of this subclinical inflammation, summarize the complications of chronic inflammation in FMF and propose a new strategy for treatment, based on these data. |
| | |
Authors:
|
Ilan Ben-Zvi; Avi Livneh |
Related Documents
:
|
18035773 - Circulating cytokine profiles in leprosy patients. 9767553 - Role of cytokines in the response to erythropoietin in hemodialysis patients. 20648073 - Evaluation of focal retinal function using multifocal electroretinography in patients w... |
Publication Detail:
|
Type: Journal Article Date: 2010-11-09 |
Journal Detail:
|
Title: Nature reviews. Rheumatology Volume: 7 ISSN: 1759-4804 ISO Abbreviation: Nat Rev Rheumatol Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101500080 Medline TA: Nat Rev Rheumatol Country: United States |
Other Details:
|
Languages: eng Pagination: 105-12 Citation Subset: IM |
Affiliation:
|
Department of Medicine F, Sheba Medical Center, Tel-Hashomer 52621, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultra-targeted APBI using TARGIT-a cautionary note.
Next Document: Genetic susceptibility to systemic lupus erythematosus in the genomic era.