Document Detail

Chronic inflammation in FMF: markers, risk factors, outcomes and therapy.
MedLine Citation:
PMID:  21060333     Owner:  NLM     Status:  In-Data-Review    
Familial Mediterranean fever (FMF) is the most common of the hereditary periodic fever syndromes. Although the typical clinical course of FMF is characterized by bouts of painful inflammation, this presentation represents only the tip of the iceberg. In many patients inflammation can persist in attack-free periods, as shown by high levels of acute-phase proteins, cytokines and inflammation-induced proteins. This subclinical inflammation puts patients at risk of developing complications such as anemia, splenomegaly, decreased bone mineral density, heart disease and life-threatening amyloid A amyloidosis, among others. In this article, we review the published data on markers and other factors involved in the persistence of inflammation in patients with FMF during attack-free periods, examine the risk factors for the development of this subclinical inflammation, summarize the complications of chronic inflammation in FMF and propose a new strategy for treatment, based on these data.
Ilan Ben-Zvi; Avi Livneh
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Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  Nature reviews. Rheumatology     Volume:  7     ISSN:  1759-4804     ISO Abbreviation:  Nat Rev Rheumatol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500080     Medline TA:  Nat Rev Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-12     Citation Subset:  IM    
Department of Medicine F, Sheba Medical Center, Tel-Hashomer 52621, Israel.
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