Document Detail


Chronic inflammation and aging: DNA damage tips the balance.
MedLine Citation:
PMID:  22565047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aged immune system, typically hyporesponsive to infection and vaccination, can be hyperresponsive in the context of inflammatory pathology. Here we review current work examining the mechanisms behind the amplified inflammatory profile of aged adaptive immunity, and the reciprocal relationship between chronic inflammation and immune aging. Aged hematopoietic stem cells are driven to differentiate following accumulated DNA damage, thus depleting the stem cell pool and increasing the number of damaged effector cells in the circulation. Chronic DNA damage responses in lymphocytes as well as senescent cells of other lineages initiate the production of inflammatory mediators. In addition, aged lymphocytes become less reliant on specific antigen for stimulation and more prone to activation through innate receptors. When these lymphocytes are exposed to inflammatory signals produced by senescent tissues, the bias toward inflammation exacerbates destruction without necessarily improving immunity.
Authors:
Mary M Cavanagh; Cornelia M Weyand; Jörg J Goronzy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-05-05
Journal Detail:
Title:  Current opinion in immunology     Volume:  24     ISSN:  1879-0372     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2012-12-07     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  488-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Aging / physiology*
Chronic Disease
DNA Damage*
Humans
Immune System / physiology*
Immunity
Inflammation / immunology*
Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
P01 HL058000/HL/NHLBI NIH HHS; P01 HL058000/HL/NHLBI NIH HHS; R01 AI044142/AI/NIAID NIH HHS; R01 AI44142/AI/NIAID NIH HHS; R01 AR042527/AR/NIAMS NIH HHS; R01 AR42527/AR/NIAMS NIH HHS; R01 EY011916/EY/NEI NIH HHS; R01 EY11916/EY/NEI NIH HHS; R01 HL039006/HL/NHLBI NIH HHS; R01 HL117913/HL/NHLBI NIH HHS; U19 AI 57266/AI/NIAID NIH HHS; U19 AI057266/AI/NIAID NIH HHS; U19 AI090019/AI/NIAID NIH HHS; U19 AI090019/AI/NIAID NIH HHS
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