Document Detail


Chronic immune thrombocytopenic purpura-who needs medication?
MedLine Citation:
PMID:  20309689     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronic ITP (immune thrombocytopenic purpura; now defined as duration of more than 12 months) is not always associated with significant bleeding problems so that most children and adults can be managed expectantly with no medication unless surgery, accidents or other pathology mandate it. A cut-off platelet count of 30 x 10(9)/l divides a group with no increased mortality from those whose risk is greater and in whom medication is usually appropriate. There is increasing recognition of long-term morbidity and mortality associated with immune suppression induced by medication and more recently new concerns have arisen about the long-term vascular complications of splenectomy. A more conservative approach to medication is warranted in many patients with chronic ITP.
Authors:
Paula H B Bolton-Maggs; Victoria S L Kok
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-3-23
Journal Detail:
Title:  Annals of hematology     Volume:  -     ISSN:  1432-0584     ISO Abbreviation:  -     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Clinical Haematology, Central Manchester and Manchester Children's University NHS Foundation Trust, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK, paula.bolton-maggs@manchester.ac.uk.
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